DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and Uba6

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001100683.1	Gene:	Uba6 / 305268	RGDID:	1308324	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	94/408 - (23%)
Similarity:	154/408 - (37%)	Gaps:	98/408 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEE 77
            |..|.::.||.||..:.|..:.:::..:.:.::|:.|||.||.||::|:|:.::.:.|.|.....
  Rat    35 ESLEIDDGLYSRQRYVLGDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAW 99

  Fly    78 DFCSQFLVPRESL--NTNRAEASLTRARALNPMVDISADREPLKEKTS-EFFGQFDVVVVNGATN 139
            |..:.|.:..:.:  ..|||||.|.|...|||.|.:|:...|..|.|. .|..::..||:.....
  Rat   100 DLGTNFFLCEDDVVNERNRAEAVLHRVAELNPYVQVSSSSAPFDETTDLSFLEKYQCVVLTETKL 164

  Fly   140 EELLRIDTICRD--LGVKFIATDVWGTFGFYFASLQKHSYVEDV---------IKHKVVAN---- 189
            ....:|:..|..  ..:|||:|||.|.:...|........|.|.         |.:...||
  Rat   165 TLQKKINNFCHSHCPPIKFISTDVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFISNITQANPGIV 229

  Fly   190 ---SEKKKKYETVSIPTQRDVDYPGYSAW------------LDFDVTEPSYLRKLKRNGPGV--- 236
               .....|.||....|.|:::  |.:..            ..|.:.:.:.|......|..|
  Rat   230 TCLENHPHKLETGQFLTFREIN--GMAGLNGSVQQITVISPFSFSIGDTTELDPYLHGGIAVQVK 292

  Fly   237 ----------------------------------LLLSVLQKFRTTHKRDPSYKTREADLELLRG 267
                                              :.:..|.:|:..:.|.|:.:.::..
  Rat   293 TPKIFNFEPLESQIKHPKCLIADFSKPEAPLQIHVAMLALDQFQENYSRKPNIRCQQDS------ 351

  Fly   268 IRDELLPNSILGDEAL--------GLIF-----AQ--ISPAVAVVGGVVAQEVIKVVTKLEAPHR 317
              ||||..:|...|.|        .::.     ||  :.|..|.||||.:|||:|.||...:|..
  Rat   352 --DELLKLTICISETLEEKPEVNADIVHWLSWTAQGFLPPLAAAVGGVASQEVLKAVTGKFSPLC 414

  Fly   318 NLFVFDPETCAGYVEAIG 335
            .....:   .|..||::|
  Rat   415 QWLYLE---AADTVESLG 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	47/157 (30%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	45/149 (30%)
Uba6	NP_001100683.1	Ube1	38..1046	CDD:273603	93/405 (23%)
		Ube1_repeat1	43..428	CDD:238768	91/397 (23%)
		E1_4HB	298..358	CDD:292809	8/67 (12%)
		Ube1_repeat2	462..1005	CDD:238767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810