DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and Uba3

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_476553.1	Gene:	Uba3 / 117553	RGDID:	621084	Length:	462	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	66/336 - (19%)
Similarity:	115/336 - (34%)	Gaps:	105/336 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTR 101
            |.|.|:|:.|..|||.|:.||:.|||...:.::|...:...:...|||...:.:...:||.:
  Rat    67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVA--- 128

  Fly   102 ARALN---PMVDISADREPLKEKTSEFFGQFDVVV-----------VNGATNEELLRIDTICRDL 152
            |..||   |..::......:::....|:.||.::|           :||      :.|..:..:.
  Rat   129 AEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWING------MLISLLNYED 187

  Fly   153 GV----KFIATDVWGTFGF-------------------------------YFASLQKHSYVEDVI 182
            ||    ..:.....||.||                               ..||:.:  ..|..|
  Rat   188 GVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPR--LPEHCI 250

  Fly   183 KHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRT 247
            ::..:....|::.:.. .:|.  |.|.|.:..|:                            |:.
  Rat   251 EYVRMLQWPKEQPFGD-GVPL--DGDDPEHIQWI----------------------------FQK 284

  Fly   248 THKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKL 312
            :.:|...|..|.....|.:|:...::|              .::...||:..|.|.||.|:.|..
  Rat   285 SVERASQYNIRGVTYRLTQGVVKRIIP--------------AVASTNAVIAAVCATEVFKIATSA 335

  Fly   313 EAPHRNLFVFD 323
            ..|..|..||:
  Rat   336 YIPLNNYLVFN 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	38/183 (21%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	35/147 (24%)
Uba3	NP_476553.1	Interaction with UBE2M N-terminus. /evidence=ECO:0000250	53..70		1/2 (50%)
		Uba3_RUB	71..368	CDD:238765	64/332 (19%)
		Interaction with UBE2M N-terminus. /evidence=ECO:0000250	157..161		2/3 (67%)
		Interaction with UBE2M N-terminus. /evidence=ECO:0000250	192..217		4/24 (17%)
		Interaction with NEDD8. /evidence=ECO:0000250	227..229		0/1 (0%)
		Interaction with NAE1. /evidence=ECO:0000250	242..248		0/7 (0%)
		Interaction with NAE1. /evidence=ECO:0000250	292..295		1/2 (50%)
		Interaction with UBE2M N-terminus. /evidence=ECO:0000250	331..338		1/6 (17%)
		Interaction with NEDD8. /evidence=ECO:0000250	352..357
		Interaction with UBE2M core domain. /evidence=ECO:0000250	368..462
		E2_bind	376..461	CDD:400951
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810