DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and SAE1

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_005491.1	Gene:	SAE1 / 10055	HGNCID:	30660	Length:	346	Species:	Homo sapiens

Alignment Length:	349	Identity:	141/349 - (40%)
Similarity:	206/349 - (59%)	Gaps:	20/349 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLL 69
            ::..|....::|.|...|||||||||||:|||||.:::|:.||.||||||.||:||:||..:.:|
Human     2 VEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTML 66

  Fly    70 DDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVV 134
            |.:.||.||..:|||:...|:..|||||||.||:.||||||:..|.|.:::|...||.|||.|.:
Human    67 DHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCL 131

  Fly   135 NGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSE-------- 191
            ...:.:.::::|.||....:||...||:|..|:.||:|.:|.:||:  |.||...|:
Human   132 TCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEE--KTKVAKVSQGVEDGPDT 194

  Fly   192 KKKKY---ETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDP 253
            |:.|.   ||..:  ::.|.:......|:.|.:.......|||......||.||.||||...|||
Human   195 KRAKLDSSETTMV--KKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDP 257

  Fly   254 SYKTREADLELLRGIRDELLPN-----SILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLE 313
            |..|.|.|.|||..||:::|.:     .:|.::.:...|::::|..|||||::|||::|.:::.:
Human   258 SSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRD 322

  Fly   314 APHRNLFVFDPETCAGYVEAIGAK 337
            .||.|.|.||.....|.||.:|.|
Human   323 PPHNNFFFFDGMKGNGIVECLGPK 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	76/152 (50%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	73/144 (51%)
SAE1	NP_005491.1	Aos1_SUMO	16..341	CDD:238769	134/328 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152401
Domainoid	1	1.000	230	1.000	Domainoid score	I2469
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4019
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3325
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54790
OrthoDB	1	1.010	-	-		D1180926at2759
OrthoFinder	1	1.000	-	-		FOG0003336
OrthoInspector	1	1.000	-	-		oto89439
orthoMCL	1	0.900	-	-		OOG6_102966
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	1	1.000	-	-		X2228
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800