DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha2 and PRE8

DIOPT Version :9

Sequence 1:	NP_524328.1	Gene:	Prosalpha2 / 41531	FlyBaseID:	FBgn0086134	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	NP_013618.1	Gene:	PRE8 / 854882	SGDID:	S000004557	Length:	250	Species:	Saccharomyces cerevisiae

Alignment Length:	249	Identity:	135/249 - (54%)
Similarity:	168/249 - (67%)	Gaps:	18/249 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TERYSFSLTTFSPSGKLVQLEYALAAVSGGAPSVGIIASNGVVIATENKHKSPLYEQHSVHRVEM 67
            |:|||||||||||||||.|::|||.||..|..|:||.|:||||||||.|..|||....::.:|.:
Yeast     2 TDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSL 66

  Fly    68 IYNHIGMVYSGMGPDYRLLVKQARKIAQT-YYLTYKEPIPVSQLVQRVATLMQEYTQSGGVRPFG 131
            :...||.||||||||||:||.::||:|.| |...|.|..|...||..||.:|||.||||||||||
Yeast    67 LTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFG 131

  Fly   132 VSLLICGWDNDRPY-LYQSDPSGAYFAWKATAMGKNAVNGKTFLEKRYSEDLELDDAVHTAILTL 195
            |||||.|.|....: |||.||||:||.|||||:||.:|..|||||||::::|||:||:|.|:|||
Yeast   132 VSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTL 196

  Fly   196 KEGFEGKMTADNIEIGIC-DQN---------------GFQRLDPASIKDYLASI 233
            ||..||:...|.||:.|. |:|               .|::|....|.|.|.::
Yeast   197 KESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha2	NP_524328.1	proteasome_alpha_type_2	6..231	CDD:239719	132/242 (55%)
PRE8	NP_013618.1	proteasome_alpha_type_2	5..247	CDD:239719	132/241 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343121
Domainoid	1	1.000	200	1.000	Domainoid score	I562
eggNOG	1	0.900	-	-		E1_KOG0181
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2081
Inparanoid	1	1.050	243	1.000	Inparanoid score	I679
Isobase	1	0.950	-	0	Normalized mean entropy	S257
OMA	1	1.010	-	-		QHG54016
OrthoFinder	1	1.000	-	-		FOG0003690
OrthoInspector	1	1.000	-	-		oto99075
orthoMCL	1	0.900	-	-		OOG6_101969
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1004
SonicParanoid	1	1.000	-	-		X2555
TreeFam	1	0.960	-	-
	16	15.740