DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZSCAN12

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001156863.1	Gene:	ZSCAN12 / 9753	HGNCID:	13172	Length:	611	Species:	Homo sapiens

Alignment Length:	460	Identity:	153/460 - (33%)
Similarity:	234/460 - (50%)	Gaps:	32/460 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLANVDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTC 65
            |.|.::..:|..:.|..|...|:.|...:.:::..|:.|:        .:::||.....||.:..
Human   160 MSLQSMKAQPKYESPELESQQEQVLDVETGNEYGNLKQEV--------SEEMEPHGKTSSKFEND 216

  Fly    66 KSKIAK----KRPLRKQTDTFKCTQCQKTFTRKENLES---------HLRLHAEERPFECSHCSK 117
            .||.|:    :.|.....:...|::..|..|..||..|         |.|:...|..:.|..|.|
Human   217 MSKSARCGETREPEEITEEPSACSREDKQPTCDENGVSLTENSDHTEHQRICPGEESYGCDDCGK 281

  Fly   118 SFGRRTHYKRHLLKHEK-----RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARK 177
            :|.:.:    ||::|::     ||:||..|.|.|...:.|.:|...||||:|:||.:|..:|.|.
Human   282 AFSQHS----HLIEHQRIHTGDRPYKCEECGKAFRGRTVLIRHKIIHTGEKPYKCNECGKAFGRW 342

  Fly   178 SHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLT 242
            |.|..|.|.|:.|:.:.|..|.|||...:.|..|::.|...:|::|:.|:|||..||||.:|...
Human   343 SALNQHQRLHTGEKHYHCNDCGKAFSQKAGLFHHIKIHTRDKPYQCTQCNKSFSRRSILTQHQGV 407

  Fly   243 H-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKC 306
            | ..:.::|.:|.|.|:.|.||..|..:|..|..::|..|.::|:::..:| |...|.|::|.||
Human   408 HTGAKPYECNECGKAFVYNSSLVSHQEIHHKEKCYQCKECGKSFSQSGLIQ-HQRIHTGEKPYKC 471

  Fly   307 SQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKC 371
            ..|...|..|:....|.|:||.||.|||.:|.|:|.::|.|.|||::||||||:||..|...|:.
Human   472 DVCEKAFIQRTSLTEHQRIHTGERPYKCDKCGKAFTQRSVLTEHQRIHTGERPYKCDECGNAFRG 536

  Fly   372 RTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLR 436
            .|.|..|...|.|||..:|..|.|.|:..|.|..|.:.|..:..:.|..|.||:..:|.|..|..
Human   537 ITSLIQHQRIHTGEKPYQCDECGKAFRQRSDLSKHQRIHNRRGTYVCKECGKSFRQNSALTQHQT 601

  Fly   437 THTGE 441
            .|.||
Human   602 IHKGE 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	137/383 (36%)
		C2H2 Zn finger	84..104	CDD:275368	8/28 (29%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..492	CDD:275368
ZSCAN12	NP_001156863.1	SCAN	42..152	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..175		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..264		15/73 (21%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..296	CDD:275368	7/23 (30%)
		COG5048	299..579	CDD:227381	110/280 (39%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	10/19 (53%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..463	CDD:275368	5/19 (26%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810