Protein Alignment CG5245 and ZNF432

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_055465.1
• Gene: ZNF432 / 9668
• HGNCID: 20810
• Length: 652
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 173/477 - (36%)
• Similarity: 244/477 - (51%)
• Gaps: 27/477 - (5%)

  Fly    30 NSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRK 94
            :.::|||.|..|.              .|.:|..:.||:::|.:...:......|::|.|.|.:|
Human   167 HGNYEELYSAAKF--------------SVSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKK 217

  Fly    95 ENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHK------CSHCSKTFTQNSSLK 153
            ..|..|.|:|..|:|:.|:.|:|.|.|::....|     :|.||      ||.|.|.||..|.|.
Human   218 SQLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEH-----QRIHKREKSFICSECGKVFTMKSRLI 277

  Fly   154 QHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEA 218
            :|...||||:|:.|.:|...|..|.:|.||.|.|:.|:.:.|:.|.|.|...|.|..|.|||...
Human   278 EHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTGEKSYICSECGKGFTGKSMLIIHQRTHTGE 342

  Fly   219 RPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCS 282
            :|:.||.|.|.|..:..:..|...| .|:.:.|.:|.|.|.....:..|.|.|.||.|:.|..|.
Human   343 KPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFTMKSRMIEHQRTHTGEKPYICSECG 407

  Fly   283 ETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHL 347
            :.|.|.|.|.:|...|..::...||:|...|.::|:..:|.|.||.|:.|.|:||.|.|..||.|
Human   408 KGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLIIHQRTHTGEKPYTCSECGKGFPLKSRL 472

  Fly   348 VEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTG 412
            :.||:.||||:|::|:.|.|.|...:.|.:|...|.|||...|:.|.|.|...|.|:||.:.|||
Human   473 IVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNECGKGFAFKSNLVVHQRTHTG 537

  Fly   413 KNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHC 477
            :..|.|..|.|.:|....|.:|.:.||.|....||.|.:.||:..|...|.:.|||||||.|:.|
Human   538 EKPFMCSECGKGFTMKRYLIVHQQIHTEEKSCICSECGRGFAKETELALHKQVHTGEKPYGCNEC 602

  Fly   478 STRYTQKSSLGRHLRRTLCGTK 499
            ...:|.||.|..| :||..|.|
Human   603 GKGFTMKSRLIVH-QRTHTGEK 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	153/410 (37%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF432	NP_055465.1	KRAB	8..68	CDD:214630
		COG5048	<87..380	CDD:227381	75/231 (32%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		C2H2 Zn finger	235..255	CDD:275368	7/24 (29%)
		COG5048	259..636	CDD:227381	143/366 (39%)
		C2H2 Zn finger	263..283	CDD:275368	9/19 (47%)
		C2H2 Zn finger	291..311	CDD:275368	8/19 (42%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	10/19 (53%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)
		C2H2 Zn finger	515..535	CDD:275368	8/19 (42%)
		C2H2 Zn finger	543..563	CDD:275368	6/19 (32%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	599..619	CDD:275368	8/20 (40%)
		C2H2 Zn finger	627..647	CDD:275368