DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF461

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_694989.2	Gene:	ZNF461 / 92283	HGNCID:	21629	Length:	563	Species:	Homo sapiens

Alignment Length:	493	Identity:	154/493 - (31%)
Similarity:	244/493 - (49%)	Gaps:	63/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDEP----PQEDTFEEELI-FISNSDFEELESEIKI-----ENFCSYGKDLEPVK 56
            |||:      :|||    |:.|.:|.||. :::..:|:....|..|     |..|.:.:.....:
Human   101 DLAS------RDEPQKLSPKRDIYETELSQWVNMEEFKSHSPERSIFSAIWEGNCHFEQHQGQEE 159

  Fly    57 GVPSKLKTCKSKIAKKRPLRKQ----TDTF-------KCTQCQKTFTRKENLESHLRLHAEERPF 110
            |...:|......:    |:..|    |..|       :|.:|:|.|:.......|.|.|::|..
Human   160 GYFRQLMINHENM----PIFSQHTLLTQEFYDREKISECKKCRKIFSYHLFFSHHKRTHSKELS- 219

  Fly   111 ECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFA 175
            ||..|::.......:|:..:::..:.::|..|.|.|...|.|| ||..|.||:.::|.:|..:|.
Human   220 ECKECTEIVNTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLK-HLRIHNGEKRYECNECGKAFN 283

  Fly   176 RKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHL 240
            ..|.|.:|.|.|:.|:|:||..|.|||:..|.|.:|.|.|...:|::|..|.|:|
Human   284 YGSELTLHQRIHTGEKPYECKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAF---------- 338

  Fly   241 LTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLK 305
                .|.|:.|:             |||:|.||.|::|..|.:||...|.|.:|...|.|::|.:
Human   339 ----IRGFQLTE-------------HLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYE 386

  Fly   306 CSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFK 370
            |.:|...|:..|.:..|.::|:.::.|:|.||.|:|.....|..||::||||:|::|..|.|.|:
Human   387 CRECGKAFSYHSSFSHHQKIHSGKKPYECHECGKAFCDGLQLTLHQRIHTGEKPYECKECGKTFR 451

  Fly   371 CRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHL 435
            ..:||:.|...|.|||..:|..|.|.|:|.|.|:.|.:.|||:..:||..|.|:::..|:...|.
Human   452 QCSHLKRHQRIHTGEKPHECMICGKAFRLHSHLIQHQRIHTGEKPYECKECGKAFSYHSSFSHHQ 516

  Fly   436 RTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYK 473
            |.|:|:.|::   |.|.|....:...|...||||||.:
Human   517 RIHSGKKPYQ---CGKAFNHRLQLNLHQTLHTGEKPVR 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	136/411 (33%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	250..270	CDD:275368	4/19 (21%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	4/19 (21%)
		C2H2 Zn finger	474..492	CDD:275368	154/493 (31%)
ZNF461	NP_694989.2	KRAB	6..66	CDD:214630
		C2H2 Zn finger	248..267	CDD:275368	9/19 (47%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..312	CDD:316026	12/24 (50%)
		C2H2 Zn finger	303..323	CDD:275368	9/19 (47%)
		COG5048	<312..515	CDD:227381	77/229 (34%)
		C2H2 Zn finger	331..351	CDD:275368	10/46 (22%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..544	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900