DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF765

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001035275.1	Gene:	ZNF765 / 91661	HGNCID:	25092	Length:	523	Species:	Homo sapiens

Alignment Length:	510	Identity:	161/510 - (31%)
Similarity:	239/510 - (46%)	Gaps:	99/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DTFKCTQ-CQKTFTRKENLESHLRLHAEERPFEC---SHCSKSFGRRTHY-----KRHLLKH--- 132
            :.:||.. .|:|..|...||::..|.:.:...:|   ...|.:.|.|..:     :||...|
Human    20 EEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNREVFHAGTSQRHESHHNGD 84

  Fly   133 --------------------EKRPH--------KCSHCSKTFTQN------------SSLKQHLH 157
                                |:..|        |.:..::.:.||            .|...||.
Human    85 FCFQDIDKDIHDIEFQWQEDERNGHEALMTKIKKLTGSTERYDQNYAGNKPVKYQLGFSFHSHLP 149

  Fly   158 E----HTGER----------------PFKCTQC----------------STSFARKSHLQVHLRT 186
            |    ||.|:                ..:...|                |:.|.:|.  :||:|
Human   150 ELHIFHTEEKIDNQVVKSIHDASLVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQ--EVHMR- 211

  Fly   187 HSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKC 250
               |:.|:|....||:..:|.|::|...|...:.:||..|.|.|..:..:.:|...| .|:.:||
Human   212 ---EKSFQCNDSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKC 273

  Fly   251 TQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAM 315
            .:|.|||.|...|..|.|:|.||.|:||..|.:.|...|:||:|...|.|::|.||::|..||:.
Human   274 NECGKTFSQTYYLTCHRRLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQ 338

  Fly   316 RSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHML 380
            :|....|.||||.|:.|||.||.|:|.:|||...|.:|||||:|:||..|.|.|..::.|..|..
Human   339 KSYLTCHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRR 403

  Fly   381 DHIGEKVPKCSYCSKEFKLSSQLLVHL-QEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444
            .|..||..||:.|.|.|  :.||.::: :.|:|:..::|..|.|:|:..|.|.:|.:.||.|.|:
Human   404 LHTEEKPYKCNECGKTF--NQQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTEENPY 466

  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTK 499
            ||:.|.|.|:|::....|.|.|||:|||||..|...::.||:|.|| ||...|.|
Human   467 KCNECGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSNLERH-RRIYTGEK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	151/487 (31%)
		C2H2 Zn finger	84..104	CDD:275368	6/20 (30%)
		C2H2 Zn finger	112..132	CDD:275368	6/27 (22%)
		C2H2 Zn finger	139..159	CDD:275368	6/35 (17%)
		C2H2 Zn finger	167..187	CDD:275368	7/35 (20%)
		zf-H2C2_2	179..204	CDD:290200	8/24 (33%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/20 (30%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF765	NP_001035275.1	KRAB	8..>48	CDD:214630	8/27 (30%)
		KRAB	8..47	CDD:279668	8/26 (31%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		zf-H2C2_2	230..254	CDD:290200	8/23 (35%)
		C2H2 Zn finger	245..265	CDD:275368	5/19 (26%)
		zf-H2C2_2	260..282	CDD:290200	9/21 (43%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	285..309	CDD:290200	10/23 (43%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..338	CDD:290200	11/23 (48%)
		COG5048	<325..477	CDD:227381	65/153 (42%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	341..366	CDD:290200	13/24 (54%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	10/26 (38%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		zf-H2C2_2	452..477	CDD:290200	11/24 (46%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		C2H2 Zn finger	496..515	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900