DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5245 and ZNF439

DIOPT Version :9

Sequence 1:NP_650197.1 Gene:CG5245 / 41530 FlyBaseID:FBgn0038047 Length:501 Species:Drosophila melanogaster
Sequence 2:NP_001335647.1 Gene:ZNF439 / 90594 HGNCID:20873 Length:507 Species:Homo sapiens


Alignment Length:412 Identity:132/412 - (32%)
Similarity:202/412 - (49%) Gaps:33/412 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 EELESEIKIENFCSYGKDLEPV---------KGVPSKLKTCKSKIAK------KRPLRKQTDT-F 82
            ||..:|||.::.|  |:...||         |....::|:|.|.:.:      ...:..:.|| .
Human    91 EEKVNEIKEDSHC--GETFTPVPDDRLNFQKKKASPEVKSCDSFVCEVGLGNSSSNMNIRGDTGH 153

  Fly    83 KCTQCQ-------------KTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE- 133
            |..:||             |.|....:|.:..|.|..::|:.|..|.|:....:..:||::.|. 
Human   154 KACECQEYGPKPWKSQQPKKAFRYHPSLRTQERDHTGKKPYACKECGKNIIYHSSIQRHMVVHSG 218

  Fly   134 KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHC 198
            ..|:||..|.|.|...|....|...||||:|::|.||..||:..:..::|.|||..|:|:||..|
Human   219 DGPYKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATHRIHERTHIGEKPYECQEC 283

  Fly   199 EKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERS-FKCTQCPKTFLQNDS 262
            .|||.:......|.|:|...:.::|..|.|:|.....:::|..||:.:. ::|.||.|......|
Human   284 GKAFHSPRSCHRHERSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQCGKALSSLTS 348

  Fly   263 LQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHT 327
            .|.|:|:|:||.|::|..|.:.|......|.|...|:|::|.||.||...|.....:|.|.|.||
Human   349 FQTHIRMHSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYHERTHT 413

  Fly   328 RERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSY 392
            .|:.|:|.:|.|:|....:|..|.:.||||:|::|..|.|.|:..:.||:|...|.|||..:|..
Human   414 GEKPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGKAFRSASQLRIHRRIHTGEKPYECKK 478

  Fly   393 CSKEFKLSSQLLVHLQEHTGKN 414
            |.|.|:.......|.:..|.||
Human   479 CGKAFRYVQNFRFHERTQTHKN 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5245NP_650197.1 COG5048 74..478 CDD:227381 119/357 (33%)
C2H2 Zn finger 84..104 CDD:275368 6/32 (19%)
C2H2 Zn finger 112..132 CDD:275368 5/19 (26%)
C2H2 Zn finger 139..159 CDD:275368 6/19 (32%)
C2H2 Zn finger 167..187 CDD:275368 7/19 (37%)
zf-H2C2_2 179..204 CDD:290200 12/24 (50%)
C2H2 Zn finger 195..215 CDD:275368 7/19 (37%)
C2H2 Zn finger 223..243 CDD:275368 5/19 (26%)
C2H2 Zn finger 250..270 CDD:275368 8/19 (42%)
C2H2 Zn finger 278..298 CDD:275368 5/19 (26%)
C2H2 Zn finger 306..326 CDD:275368 7/19 (37%)
C2H2 Zn finger 334..354 CDD:275368 6/19 (32%)
C2H2 Zn finger 362..382 CDD:275368 7/19 (37%)
C2H2 Zn finger 390..410 CDD:275368 5/19 (26%)
C2H2 Zn finger 418..438 CDD:275368
C2H2 Zn finger 446..466 CDD:275368
C2H2 Zn finger 474..492 CDD:275368
ZNF439NP_001335647.1 KRAB 26..67 CDD:307490
C2H2 Zn finger 196..216 CDD:275368 5/19 (26%)
COG5048 <204..381 CDD:227381 59/176 (34%)
C2H2 Zn finger 224..244 CDD:275368 6/19 (32%)
C2H2 Zn finger 252..272 CDD:275368 7/19 (37%)
C2H2 Zn finger 280..300 CDD:275368 7/19 (37%)
C2H2 Zn finger 308..328 CDD:275368 5/19 (26%)
COG5048 <321..492 CDD:227381 61/170 (36%)
C2H2 Zn finger 336..356 CDD:275368 8/19 (42%)
C2H2 Zn finger 364..384 CDD:275368 5/19 (26%)
C2H2 Zn finger 392..412 CDD:275368 7/19 (37%)
C2H2 Zn finger 420..440 CDD:275368 6/19 (32%)
C2H2 Zn finger 448..468 CDD:275368 7/19 (37%)
C2H2 Zn finger 476..495 CDD:275368 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100020
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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