DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5245 and ZNF468

DIOPT Version :9

Sequence 1:NP_650197.1 Gene:CG5245 / 41530 FlyBaseID:FBgn0038047 Length:501 Species:Drosophila melanogaster
Sequence 2:XP_016882932.1 Gene:ZNF468 / 90333 HGNCID:33105 Length:541 Species:Homo sapiens


Alignment Length:444 Identity:148/444 - (33%)
Similarity:206/444 - (46%) Gaps:85/444 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ESEIKIENFCSYGKDLEPVKGVPSKLKTC---KSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLE 98
            :||.||.|  ...|.:.....|.:..:.|   |:.|:.|                   ....:|.
Human   174 QSEGKIGN--QVEKSINNASSVSTSQRICCRPKTHISNK-------------------YGNNSLH 217

  Fly    99 SHL-----RLHAEERPFECSHCSKSFGRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLH 157
            |.|     .:|..|:.|||....|||...:..|:|.:.| |::..||..|.|.|.|...|..|..
Human   218 SSLLTQKWEVHMREKSFECIQSFKSFNCSSLLKKHQIIHLEEKQCKCDVCGKVFNQKRYLACHRR 282

  Fly   158 EHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFK 222
            .||||:|:||.:|..:|...|.|.:|...|:.|:|:||..|:|.|...|||:.            
Human   283 CHTGEKPYKCNECGKTFGHNSSLFIHKALHTGEKPYECEECDKVFSRKSHLER------------ 335

  Fly   223 CSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFAR 287
                                                       |.|:|.||.|:||..|.|.||.
Human   336 -------------------------------------------HKRIHTGEKPYKCKVCDEAFAY 357

  Fly   288 NSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQ 352
            ||.|..|.:.|.|::|..|::|...|...|....|.||||.|:.|||.||.|.|.:||||..|::
Human   358 NSYLAKHTILHTGEKPYTCNECGKVFNRLSTLARHHRLHTGEKPYKCEECDKVFSRKSHLERHRR 422

  Fly   353 VHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFE 417
            :|:||:|:||..|.|.|..:::|..|...|.|||..||..|.|.|:..|.|..|.:.|||:..::
Human   423 IHSGEKPYKCEECCKVFSRKSNLERHRRIHTGEKPYKCKVCDKAFQRDSHLAQHQRVHTGEKPYK 487

  Fly   418 CPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKP 471
            |..|.|::..:|:|.:|.|.||||.|:||:.|.|.|::.:....|.|.|:||||
Human   488 CNECGKTFGQTSSLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKP 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5245NP_650197.1 COG5048 74..478 CDD:227381 137/404 (34%)
C2H2 Zn finger 84..104 CDD:275368 3/24 (13%)
C2H2 Zn finger 112..132 CDD:275368 6/19 (32%)
C2H2 Zn finger 139..159 CDD:275368 7/19 (37%)
C2H2 Zn finger 167..187 CDD:275368 6/19 (32%)
zf-H2C2_2 179..204 CDD:290200 10/24 (42%)
C2H2 Zn finger 195..215 CDD:275368 7/19 (37%)
C2H2 Zn finger 223..243 CDD:275368 0/19 (0%)
C2H2 Zn finger 250..270 CDD:275368 2/19 (11%)
C2H2 Zn finger 278..298 CDD:275368 9/19 (47%)
C2H2 Zn finger 306..326 CDD:275368 6/19 (32%)
C2H2 Zn finger 334..354 CDD:275368 10/19 (53%)
C2H2 Zn finger 362..382 CDD:275368 6/19 (32%)
C2H2 Zn finger 390..410 CDD:275368 7/19 (37%)
C2H2 Zn finger 418..438 CDD:275368 7/19 (37%)
C2H2 Zn finger 446..466 CDD:275368 6/19 (32%)
C2H2 Zn finger 474..492 CDD:275368
ZNF468XP_016882932.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100020
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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