DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF551

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_612356.2	Gene:	ZNF551 / 90233	HGNCID:	25108	Length:	670	Species:	Homo sapiens

Alignment Length:	493	Identity:	176/493 - (35%)
Similarity:	276/493 - (55%)	Gaps:	23/493 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCK 66
            ||...:..|..:||             .:|..:.:::....:::..:|:        ..|..:.|
Human   192 DLLQHEATPSGEEP-------------HSSSSKHIQAFFNAKSYYKWGE--------YRKASSHK 235

  Fly    67 SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLK 131
            ..:.:.:.:..:...::|::|:|.||.|..|..|.::|..::.||||.|.:||.::.|...|.:.
Human   236 HTLVQHQSVCSEGGLYECSKCEKAFTCKNTLVQHQQIHTGQKMFECSECEESFSKKCHLILHKII 300

  Fly   132 HE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFEC 195
            |. :||::||...|.|...|....|...|||....:|.:|..:|:.||:|..|.|.|:.|||:||
Human   301 HTGERPYECSDREKAFIHKSEFIHHQRRHTGGVRHECGECRKTFSYKSNLIEHQRVHTGERPYEC 365

  Fly   196 THCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQ 259
            ..|.|:|:.:|.|..|.|.|...||::|..|.|||:....|.:|...| .|..::|:.|.|:|..
Human   366 GECGKSFRQSSSLFRHQRVHSGERPYQCCECGKSFRQIFNLIRHRRVHTGEMPYQCSDCGKSFSC 430

  Fly   260 NDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVR 324
            ...|..|.|:|:||.|::|..|.::|.:.|.|..|...|.|..|.:||:|..:|:.:.:...|.|
Human   431 KSELIQHQRIHSGERPYECRECGKSFRQFSNLIRHRSIHTGDRPYECSECEKSFSRKFILIQHQR 495

  Fly   325 LHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPK 389
            :||.||.|:|:||.|||.:||.|::|:::|||.||::|:.|.|.|:.|:.|..|...|.||:..:
Human   496 VHTGERPYECSECGKSFTRKSDLIQHRRIHTGTRPYECSECGKSFRQRSGLIQHRRLHTGERPYE 560

  Fly   390 CSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFA 454
            ||.|.|.|..|:.|:.|.:.|||:..:||..|.||::.||:|..|.|.||||.|::||.|.|.|.
Human   561 CSECGKSFSQSASLIQHQRVHTGERPYECSECGKSFSQSSSLIQHQRGHTGERPYECSQCGKPFT 625

  Fly   455 RSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            ..::..:|.|.||||:||:||.|...:::||:|.||.|
Human   626 HKSDLIQHQRVHTGERPYECSECGKSFSRKSNLIRHRR 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	160/405 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	8/17 (47%)
ZNF551	NP_612356.2	KRAB	29..>71	CDD:214630
		KRAB	29..68	CDD:279668
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		COG5048	279..624	CDD:227381	140/344 (41%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..329	CDD:275368	4/17 (24%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	349..374	CDD:290200	12/24 (50%)
		C2H2 Zn finger	365..385	CDD:275368	8/19 (42%)
		zf-H2C2_2	377..402	CDD:290200	11/24 (46%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		zf-H2C2_2	405..430	CDD:290200	8/24 (33%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		zf-H2C2_2	433..458	CDD:290200	10/24 (42%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		zf-H2C2_2	461..486	CDD:290200	9/24 (38%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		zf-H2C2_2	490..514	CDD:290200	13/23 (57%)
		C2H2 Zn finger	505..525	CDD:275368	10/19 (53%)
		zf-H2C2_2	517..542	CDD:290200	11/24 (46%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		zf-H2C2_2	546..570	CDD:290200	10/23 (43%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		zf-H2C2_2	573..598	CDD:290200	10/24 (42%)
		C2H2 Zn finger	589..609	CDD:275368	9/19 (47%)
		C2H2 Zn finger	617..637	CDD:275368	7/19 (37%)
		zf-H2C2_2	629..654	CDD:290200	11/24 (46%)
		C2H2 Zn finger	645..665	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900