DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF587

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_116217.1	Gene:	ZNF587 / 84914	HGNCID:	30955	Length:	575	Species:	Homo sapiens

Alignment Length:	465	Identity:	155/465 - (33%)
Similarity:	225/465 - (48%)	Gaps:	75/465 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FCSYGKDLEPVKGVPSKLKTCKSKIAKKR---------PLRKQTDTFKCTQCQKTFTRKENLESH 100
            |..:|||:.|..|:      |:.:.|.::         |.::....:.|.:..|.|:.|.::..|
Human   172 FREFGKDVLPSSGL------CQEEAAVEKTDSETMHGPPFQEGKTNYSCGKRTKAFSTKHSVIPH 230

  Fly   101 LRLHAEERPFECSHCSKSFGRRTHYKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERP 164
            .:|...:..:.||.|.|||.|...:..|...| .|.|:.|..|.|::::.|||.||...|||:..
Human   231 QKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSYSRKSSLIQHQRVHTGQTA 295

  Fly   165 FKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKS 229
            :.|.:|..||::|..|..|...|:.|.|:||..|.|:|....:|.:|.:.|...|.:.|..|.||
Human   296 YPCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFGQKGNLIQHQQGHTGERAYHCGECGKS 360

  Fly   230 FKLRSILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLH 294
            |:     ||....:                      |.|||.||.|:||..|.::|.:...| :|
Human   361 FR-----QKFCFIN----------------------HQRVHTGERPYKCGECGKSFGQKGNL-VH 397

  Fly   295 LLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERP 359
                                       |.|.||.||.|:|.||.|||..:|||.|||::||||||
Human   398 ---------------------------HQRGHTGERPYECKECGKSFRYRSHLTEHQRLHTGERP 435

  Fly   360 FKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKS 424
            :.|..|.|.|..:.||.||...|.||:...|..|.|.|.....:.:|.:.|||:..:||..|.||
Human   436 YNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKLFGNKHSVTIHQRIHTGERPYECSECGKS 500

  Fly   425 YTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSL-- 487
            :.:||.||:|.|.|:|:.|:|||.|.|.|:..:...:|.|.||||:||:|:.|...:.:.|:|
Human   501 FLSSSALHVHKRVHSGQKPYKCSECGKSFSECSSLIKHRRIHTGERPYECTKCGKTFQRSSTLLH 565

  Fly   488 --GRHLRRTL 495
              ..|.|:.|
Human   566 HQSSHRRKAL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	141/404 (35%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	2/19 (11%)
		C2H2 Zn finger	334..354	CDD:275368	12/19 (63%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	418..438	CDD:275368	10/19 (53%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/21 (24%)
ZNF587	NP_116217.1	KRAB	15..70	CDD:214630
		KRAB	15..54	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	122..142	CDD:275368
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		COG5048	<273..568	CDD:227381	125/349 (36%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	326..343	CDD:275368	5/16 (31%)
		C2H2 Zn finger	354..374	CDD:275368	9/46 (20%)
		zf-H2C2_2	369..389	CDD:290200	10/41 (24%)
		C2H2 Zn finger	382..402	CDD:275368	7/47 (15%)
		zf-H2C2_2	394..419	CDD:290200	15/52 (29%)
		C2H2 Zn finger	410..430	CDD:275368	12/19 (63%)
		zf-H2C2_2	422..447	CDD:290200	15/24 (63%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		zf-H2C2_2	450..473	CDD:290200	10/22 (45%)
		C2H2 Zn finger	466..486	CDD:275368	5/19 (26%)
		zf-H2C2_2	478..503	CDD:290200	9/24 (38%)
		C2H2 Zn finger	494..514	CDD:275368	10/19 (53%)
		zf-H2C2_2	509..530	CDD:290200	10/20 (50%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		zf-H2C2_2	534..557	CDD:290200	10/22 (45%)
		C2H2 Zn finger	550..570	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900