DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF382

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_116214.2	Gene:	ZNF382 / 84911	HGNCID:	17409	Length:	550	Species:	Homo sapiens

Alignment Length:	487	Identity:	149/487 - (30%)
Similarity:	213/487 - (43%)	Gaps:	98/487 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EDTFEEELIFISNSDFEELESEIKIENF------------CSYGKDLEPVKGV------------ 58
            :|.....||||::....:..|.|..:.|            |.|..|.:.:|.:
Human    94 QDRHSRPLIFINHKKLIKERSNIYGKTFTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIK 158

  Fly    59 ----------PSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECS 113
                      .|.|.|...||.....|.|||        ::..:.|:.|..|.::.|.|:||:.:
Human   159 EKFGDSTGWEKSLLNTKHEKIHPAVNLHKQT--------ERVLSGKQELIQHQKVQAPEQPFDHN 215

  Fly   114 HCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKS 178
            .|.|||         |:|           ...||       |...|.|||.|:..:...:|..||
Human   216 ECEKSF---------LMK-----------GMLFT-------HTRAHRGERTFEYNKDGIAFIEKS 253

  Fly   179 HLQVH----------------------------LRTHSEERPFECTHCEKAFKNNSHLQEHLRTH 215
            .|.||                            .|..:||:||.|.:|...|:..|:|.||.|.|
Human   254 SLSVHPSNLMEKKPSAYNKYGKFLCRKPVFIMPQRPQTEEKPFHCPYCGNNFRRKSYLIEHQRIH 318

  Fly   216 QEARPFKCSHCSKSFKLRSILQKHLLTHAE-RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCP 279
            ...:|:.|:.|.|:|:.::.|..|..||.| :.|.|..|.|:|.|..:|..|.:.|.||..::||
Human   319 TGEKPYVCNQCGKAFRQKTALTLHEKTHIEGKPFICIDCGKSFRQKATLTRHHKTHTGEKAYECP 383

  Fly   280 HCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKK 344
            .|...|.:.|.|..|...|.|::|.:|::|...|..::...||.|.||.|:.|.|.||.|||.:|
Human   384 QCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKAFIQKTTLTVHQRTHTGEKPYICNECGKSFCQK 448

  Fly   345 SHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQE 409
            :.|..||::||||:|:.|..|.|.|:.:..|.||...|.|||...|..|.|.|...|.|:.|.:.
Human   449 TTLTLHQRIHTGEKPYICNECGKSFRQKAILTVHHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKT 513

  Fly   410 HTGKNQFECPHCSKSYTTSSTLHMHLRTHTGE 441
            |||:..:||..|.|.::..|.|.:|.:||..|
Human   514 HTGEKPYECKQCGKFFSCKSNLIVHQKTHKVE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	132/397 (33%)
		C2H2 Zn finger	84..104	CDD:275368	3/19 (16%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		C2H2 Zn finger	167..187	CDD:275368	7/47 (15%)
		zf-H2C2_2	179..204	CDD:290200	11/52 (21%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..492	CDD:275368
ZNF382	NP_116214.2	Mediates interaction with TRIM28. /evidence=ECO:0000250	1..105		4/10 (40%)
		Represses transcription. /evidence=ECO:0000250	5..46
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		Represses transcription. /evidence=ECO:0000250	70..211		26/124 (21%)
		C2H2 Zn finger	214..234	CDD:275368	9/46 (20%)
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	296..550		97/250 (39%)
		C2H2 Zn finger	298..318	CDD:275368	8/19 (42%)
		zf-H2C2_2	310..335	CDD:290200	10/24 (42%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		COG5048	<354..533	CDD:227381	70/178 (39%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..389	CDD:290200	8/21 (38%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..419	CDD:290200	8/24 (33%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..445	CDD:290200	11/21 (52%)
		C2H2 Zn finger	438..458	CDD:275368	10/19 (53%)
		zf-H2C2_2	451..475	CDD:290200	12/23 (52%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		zf-C2H2	494..514	CDD:278523	7/19 (37%)
		zf-H2C2_2	506..531	CDD:290200	9/24 (38%)
		C2H2 Zn finger	522..542	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900