DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF577

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001357376.1	Gene:	ZNF577 / 84765	HGNCID:	28673	Length:	485	Species:	Homo sapiens

Alignment Length:	415	Identity:	126/415 - (30%)
Similarity:	185/415 - (44%)	Gaps:	93/415 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EELIFISNSDFEELESEIKIENF---CSYG-KDLEP------VKGVPSKL-------KTCKS-KI 69
            ||..|:..|. :.|..|:.:||:   .|.| :..:|      .:|.|..:       :.|.. .|
Human    35 EEWQFLDQSQ-KVLYKEVMLENYINLVSIGYRGTKPDSLFKLEQGEPPGIAEGAAHSQICPGFVI 98

  Fly    70 AKKRPLRKQTDTF-------------------KCTQCQKTFTRKENLESHLRLHAEERPFECSHC 115
            ..:|...|.:|.|                   |..:|.|..:.|..|....::.|..:|.|||.|
Human    99 QSRRYAGKDSDAFGGYGRSCLHIKRDKTLTGVKYHRCVKPSSPKSQLNDLQKICAGGKPHECSVC 163

  Fly   116 SKSFGRRTHYKRHLLKHEK-----RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFA 175
            .::|.|    |..|::|::     :||.|..|.|||.:...|.:|...||||:|.:|::|..:|:
Human   164 GRAFSR----KAQLIQHQRTERGEKPHGCGECGKTFMRKIQLTEHQRTHTGEKPHECSECGKAFS 224

  Fly   176 RKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHL 240
            |||.|.||.|||:.|:|:.|:.|.|||.....|..|.|:|...:.:.||.|.|:|.     ||..
Human   225 RKSQLMVHQRTHTGEKPYRCSKCGKAFSRKCRLNRHQRSHTGEKLYGCSVCGKAFS-----QKAY 284

  Fly   241 LTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLK 305
            ||                      .|.|:|.|:.|:||..|..||...|.|..|...|.|::|.:
Human   285 LT----------------------AHQRLHTGDKPYKCSDCGRTFYFKSDLTRHQRIHTGEKPYE 327

  Fly   306 CSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVH---------TGERPFK 361
            ||:|...|..:|....|.|.||.||.|.|.||.|:|...|.|::|::.|         |.|:|
Human   328 CSECEKAFRSKSKLIQHQRTHTGERPYSCRECGKAFAHMSVLIKHEKTHIRETAINSLTVEKP-- 390

  Fly   362 CTHCFKDFKCRTHLRVHMLDHIGEK 386
                    ..|:|..::|.:.|.|:
Human   391 --------SSRSHTSLYMSELIQEQ 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	110/346 (32%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	3/19 (16%)
		C2H2 Zn finger	390..410	CDD:275368
		C2H2 Zn finger	418..438	CDD:275368
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..492	CDD:275368
ZNF577	NP_001357376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	25..83	CDD:214630	13/48 (27%)
		COG5048	136..>217	CDD:227381	28/84 (33%)
		C2H2 Zn finger	160..180	CDD:275368	8/23 (35%)
		C2H2 Zn finger	188..208	CDD:275368	7/19 (37%)
		COG5048	<194..399	CDD:227381	83/241 (34%)
		C2H2 Zn finger	216..236	CDD:275368	10/19 (53%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..292	CDD:275368	11/46 (24%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	328..348	CDD:275368	7/19 (37%)
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910