DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF528

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006723481.1	Gene:	ZNF528 / 84436	HGNCID:	29384	Length:	712	Species:	Homo sapiens

Alignment Length:	503	Identity:	170/503 - (33%)
Similarity:	249/503 - (49%)	Gaps:	31/503 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKT-------- 64
            ::||.|..             |.|..|::.|.:|......|..:.:....:|.:.|.
Human   220 EKPVSDNS-------------SVSPLEKISSSVKSHLLNKYRNNFDHAPLLPQEQKAHIREKAYK 271

  Fly    65 CK--------SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGR 121
            |.        |.....:.:....:.:||::|.|.|:....|..|.|:|..|:|::|..|.|.|..
Human   272 CNEHGQVFRASASLTNQVIHNADNPYKCSECGKVFSCSSKLVIHRRMHTGEKPYKCHECGKLFSS 336

  Fly   122 RTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLR 185
            .::..:|...|. ::|:||..|.|.|..:|.|.||...||||:|:||.:|...|.:.:||..|.:
Human   337 NSNLSQHQRIHTGEKPYKCHECDKVFRSSSKLAQHQRIHTGEKPYKCHECDKVFNQIAHLVRHQK 401

  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERS-FK 249
            .|:.|:|:.|..|.|.|..:|:|.||...|...:|:||..|.|:|.:||.|..|.|.|..|. :|
Human   402 IHTGEKPYSCNKCGKVFSRHSYLAEHQTVHTGEKPYKCEECGKAFSVRSSLITHQLIHTGRKPYK 466

  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314
            |.:|.|.|.:...|..|.|:|..|.|:.|..|.:.|::.|.|..|...|..::|.||::|...|.
Human   467 CKECDKVFGRKCFLTSHQRIHTRERPYGCSQCGKIFSQKSDLIRHRKTHTDEKPYKCNKCGTAFR 531

  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379
            ..|....|..:|:.|:.|:|.||.|.|..||.|..|.::||||:|:||..|.|.|...::|..|.
Human   532 EFSDLTAHFLIHSGEKPYECKECGKVFRYKSSLTSHHRIHTGEKPYKCNRCGKVFSRSSNLVCHQ 596

  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444
            ..|.|||..||:.|.|.|..:|.|..|...|||:..:.|..|.|::...|.|..||..||.:...
Human   597 KIHTGEKPYKCNQCGKVFNQASYLTRHQIIHTGERPYRCSKCGKAFRGCSGLTAHLAIHTEKKSH 661

  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            :|..|.|:|.:.:....|.|.|.|||||||:.||..::..|.|.:|.|
Human   662 ECKECGKIFTQKSSLTNHHRIHIGEKPYKCTLCSKVFSHNSDLAQHQR 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	151/405 (37%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF528	XP_006723481.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	272..291	CDD:275368	2/18 (11%)
		COG5048	277..712	CDD:227381	158/433 (36%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		zf-H2C2_2	312..336	CDD:290200	10/23 (43%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		zf-H2C2_2	339..364	CDD:290200	8/24 (33%)
		C2H2 Zn finger	355..375	CDD:275368	8/19 (42%)
		zf-H2C2_2	368..392	CDD:290200	12/23 (52%)
		C2H2 Zn finger	383..403	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..420	CDD:290200	10/24 (42%)
		C2H2 Zn finger	411..431	CDD:275368	8/19 (42%)
		zf-H2C2_2	423..447	CDD:290200	9/23 (39%)
		C2H2 Zn finger	439..459	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-H2C2_2	535..560	CDD:290200	9/24 (38%)
		C2H2 Zn finger	551..571	CDD:275368	9/19 (47%)
		zf-H2C2_2	563..588	CDD:290200	12/24 (50%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..616	CDD:290200	11/24 (46%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		zf-H2C2_2	619..642	CDD:290200	8/22 (36%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
		zf-H2C2_2	675..700	CDD:290200	12/24 (50%)
		C2H2 Zn finger	691..711	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810