DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF34

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens

Alignment Length:	535	Identity:	176/535 - (32%)
Similarity:	244/535 - (45%)	Gaps:	88/535 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PPQ-EDTFEEELIFISNSDF-------EELESEIKIE---NFCSYG-KDLEPVKGVPSKLK---- 63
            ||| |.|||:..:::|..::       ..|..::.:|   |..|.| ....|..||.|:|:
Human    30 PPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLETYGNLVSLGVGPAGPKPGVISQLERGDE 94

  Fly    64 ---------TCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFE-CSHCSKS 118
                     :.|..:....|.......:|....|:||..::...|        .|.| |.|.|||
Human    95 PWVLDVQGTSGKEHLRVNSPALGTRTEYKELTSQETFGEEDPQGS--------EPVEACDHISKS 151

  Fly   119 FG----------------------RRTHYKRHLLKH---EKRPHKCSHCSKTFTQNSSLKQHLHE 158
            .|                      |.:.....||..   ::|||||..|.::|.|.|.|..|...
Human   152 EGSLEKLVEQRGPRAVTLTNGESSRESGGNLRLLSRPVPDQRPHKCDICEQSFEQRSYLNNHKRV 216

  Fly   159 H----------------------------TGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFEC 195
            |                            ||::...|:.|..:|...::|..|.|.|:||:|::|
Human   217 HRSKKTNTVRNSGEIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKC 281

  Fly   196 THCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQ 259
            ..|.|||..:.....|.|.|....|::|..|.|:|..|..|.||...| .|:.:||.:|.|.|..
Human   282 DECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSA 346

  Fly   260 NDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVR 324
            ..||..|.|:|.||.|:||..|.:.|:..|.|..|...|.|::|.:|.:|...|...|....|.|
Human   347 YSSLIYHQRIHTGEKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQR 411

  Fly   325 LHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPK 389
            :||.|:.|||.||.|:|.:|:.|||||:.||||:|::|..|.|.|...|||..|...|.|||..|
Human   412 IHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTGEKPYK 476

  Fly   390 CSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFA 454
            ||.|.|.|..||:|:.|.:.|.|:..:.|..|.|:::.|:.|..|.|.||||.|:|||.|.|.|.
Human   477 CSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYKCSECGKAFR 541

  Fly   455 RSAEHQEHLRTHTGE 469
            .|:...:|.|.|..|
Human   542 HSSNMCQHQRIHLRE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	157/451 (35%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	9/41 (22%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	11/19 (58%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630	14/61 (23%)
		KRAB	35..74	CDD:279668	7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		3/24 (13%)
		COG5048	188..554	CDD:227381	138/365 (38%)
		C2H2 Zn finger	197..217	CDD:275368	7/19 (37%)
		zf-C2H2	251..273	CDD:278523	6/21 (29%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	265..290	CDD:290200	12/24 (50%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-C2H2	307..329	CDD:278523	8/21 (38%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		zf-H2C2_2	321..345	CDD:290200	9/23 (39%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	349..373	CDD:290200	11/23 (48%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		zf-H2C2_2	378..402	CDD:290200	8/23 (35%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		zf-H2C2_2	405..430	CDD:290200	12/24 (50%)
		C2H2 Zn finger	421..441	CDD:275368	11/19 (58%)
		zf-H2C2_2	434..458	CDD:290200	14/23 (61%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-H2C2_2	461..486	CDD:290200	13/24 (54%)
		C2H2 Zn finger	477..497	CDD:275368	9/19 (47%)
		zf-H2C2_2	493..514	CDD:290200	6/20 (30%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		zf-H2C2_2	517..542	CDD:290200	14/24 (58%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910