DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF430

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_079465.3	Gene:	ZNF430 / 80264	HGNCID:	20808	Length:	570	Species:	Homo sapiens

Alignment Length:	506	Identity:	161/506 - (31%)
Similarity:	236/506 - (46%)	Gaps:	52/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ANVDQRPVKDEPPQEDTFEEELIFISNSDFEEL---------ESEIKIENFCSYGKDLEPVKGVP 59
            |.|||.||......:|.:.|:.|   ...|:|:         ..::::...|....:....|...
Human   101 AMVDQPPVTYSHFAQDLWPEQGI---KDSFQEVILRRYGKCGHEDLQLRTGCKSVDECNLHKECY 162

  Fly    60 SKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTH 124
            .:|..|.:        ..|::.|:..:....|.:..|.......|..::||:|..|.|||....|
Human   163 DELNQCLT--------TTQSEIFQYDKYVNVFYKFSNPNIQKIRHTGKKPFKCKKCDKSFCMLLH 219

  Fly   125 YKRHLLKH-EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
            ..:|...| .:..::|..|.|.|...|:|.:|...||||:|:||.||..:|.:.|.|..|...|:
Human   220 LTQHKRIHIRENSYQCEECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSSTLTTHKIIHT 284

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQC 253
            .|:|:.|..|.|.|..:|||..|.|.|...:|::|..|.::|...|    ||.||.
Human   285 GEKPYRCEECGKTFNRSSHLTTHKRIHTGEKPYRCEECGRAFNRSS----HLTTHK--------- 336

  Fly   254 PKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSL 318
                          .:|.||.|:||..|.:.|.::|.|..|.:.|||::|.||.:|...|...|.
Human   337 --------------IIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKPYKCEECGKAFYRFSY 387

  Fly   319 YRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHI 383
            ...|..:||.|:.|||.||.|.|...|.|.:|:::||||:|:||..|.|.|...::|..|.:.|.
Human   388 LTKHKIIHTGEKFYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFNESSNLTAHKIIHT 452

  Fly   384 GEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSH 448
            |||..||..|.|.|..|.:|..|...|:|:..::|..|.|::...|.|..|..||.|:..:|...
Human   453 GEKPYKCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHKITHIGDTSYKYLE 517

  Fly   449 CSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSL----GRHLRRTL 495
            |.|.|::|:...:|...|||||||.|......:.|.|:|    ..:.|.||
Human   518 CDKAFSQSSTLTKHKVIHTGEKPYNCEEYGKAFNQSSNLIEQSNSYWRETL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	140/404 (35%)
		C2H2 Zn finger	84..104	CDD:275368	2/19 (11%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	0/19 (0%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	4/21 (19%)
ZNF430	NP_079465.3	KRAB	35..96	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	202..562	CDD:227381	138/386 (36%)
		C2H2 Zn finger	207..227	CDD:275368	7/19 (37%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		zf-H2C2_2	248..272	CDD:290200	12/23 (52%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		zf-H2C2_2	276..300	CDD:290200	9/23 (39%)
		C2H2 Zn finger	291..311	CDD:275368	9/19 (47%)
		zf-H2C2_2	303..328	CDD:290200	9/24 (38%)
		C2H2 Zn finger	319..339	CDD:275368	8/46 (17%)
		zf-H2C2_2	331..356	CDD:290200	12/47 (26%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..395	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	8/19 (42%)
		zf-H2C2_2	416..439	CDD:290200	11/22 (50%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		zf-H2C2_2	443..468	CDD:290200	11/24 (46%)
		C2H2 Zn finger	459..479	CDD:275368	7/19 (37%)
		zf-H2C2_2	472..496	CDD:290200	7/23 (30%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)
		C2H2 Zn finger	515..535	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900