DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF614

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_079316.2	Gene:	ZNF614 / 80110	HGNCID:	24722	Length:	585	Species:	Homo sapiens

Alignment Length:	501	Identity:	159/501 - (31%)
Similarity:	232/501 - (46%)	Gaps:	52/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EELESEIKIEN-FC-------SYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKT 90
            |...::.||:| .|       |:.::..|.:.:...::.|..:...:..:......|...|...|
Human    65 EPWTTDAKIQNKNCPGIGKVDSHLQEHSPNQRLLKSVQQCNGQNTLRNIVHLSKTHFPIVQNHDT 129

  Fly    91 F-TRKENLESHL------RLHAEERPFEC--------------SHCSKSFGRRT---HYKRHLLK 131
            | ..::||:|.|      |.|....|.|.              :|....|....   |.|..:.|
Human   130 FDLYRKNLKSSLSLINQKRRHGINNPVEFIGGEKTLLHGKHERTHTKTRFSENAKCIHTKFQVFK 194

  Fly   132 HEK-----RPHKCSHCSKTFTQNSSLKQH----LHEHTGERPFKCTQCSTS--FARKSHLQVHLR 185
            |::     :||.|..|.:||.:.|.|..|    :.|:.|..  :|.:.|.|  |.:      ||:
Human   195 HQRTQKIEKPHACIECEQTFLRKSQLIYHENICIQENPGSG--QCEKLSRSVLFTK------HLK 251

  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFK 249
            |::.::........|.....|.|..|.:||.|.:.:.||.|.|.|.::..|..|..||: |:.:.
Human   252 TNTTDKICIPNEYRKGSTVKSSLITHQQTHTEEKSYMCSECGKGFTMKRYLIAHQRTHSGEKPYV 316

  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314
            |.:|.|.|....:|.:|.|.|.||.|:.|..|.:.|.....|.:|...|.|::|..||:|...|.
Human   317 CKECGKGFTVKSNLIVHQRTHTGEKPYICSECGKGFTMKRYLVVHQRTHTGEKPYMCSECGKGFT 381

  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379
            ::|...||.|.||.|:.|.|:||.|.|..|..||.||:.||||:.:.|..|.|.|..:..|.:|.
Human   382 VKSNLIVHQRSHTGEKSYICSECGKGFTVKRTLVIHQRTHTGEKSYICNECGKGFTTKRTLIIHQ 446

  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444
            ..|.|||..:|:.|.|.|.....|:.|.:.||||..|.|..|.|||:....|..|.|.||||.|:
Human   447 RTHTGEKPYECNECGKAFSQKICLIQHERCHTGKTPFVCTECGKSYSHKYGLITHQRIHTGEKPY 511

  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            :|:.|.|.|...:....|.||||||:||.||.|...::..|:|.:|
Human   512 ECNECGKAFTTKSVLNVHQRTHTGERPYGCSDCEKAFSHLSNLVKH 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/439 (33%)
		C2H2 Zn finger	84..104	CDD:275368	8/26 (31%)
		C2H2 Zn finger	112..132	CDD:275368	4/36 (11%)
		C2H2 Zn finger	139..159	CDD:275368	7/23 (30%)
		C2H2 Zn finger	167..187	CDD:275368	6/21 (29%)
		zf-H2C2_2	179..204	CDD:290200	4/24 (17%)
		C2H2 Zn finger	195..215	CDD:275368	4/19 (21%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF614	NP_079316.2	KRAB	8..68	CDD:214630	1/2 (50%)
		KRAB	8..47	CDD:279668
		COG5048	<92..350	CDD:227381	68/265 (26%)
		C2H2 Zn finger	180..199	CDD:275368	4/18 (22%)
		C2H2 Zn finger	207..226	CDD:275368	7/18 (39%)
		C2H2 Zn finger	236..253	CDD:275368	6/22 (27%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		zf-H2C2_2	301..325	CDD:290200	8/23 (35%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		zf-H2C2_2	329..353	CDD:290200	9/23 (39%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..381	CDD:290200	8/23 (35%)
		C2H2 Zn finger	373..393	CDD:275368	8/19 (42%)
		COG5048	<383..562	CDD:227381	75/175 (43%)
		C2H2 Zn finger	401..421	CDD:275368	10/19 (53%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		zf-H2C2_2	442..466	CDD:290200	10/23 (43%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	498..522	CDD:290200	12/23 (52%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	541..561	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900