Protein Alignment CG5245 and ZNF426

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_077011.1
• Gene: ZNF426 / 79088
• HGNCID: 20725
• Length: 554
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 160/534 - (29%)
• Similarity: 250/534 - (46%)
• Gaps: 98/534 - (18%)

  Fly    21 FEEELIFISNSDFEELESEIKIENFCSY----GKDLEP------------------VKGVPSKLK 63
            |.:|...:.:|....|.|::.:||:.:.    |:.::|                  ::|...:|:
Human    51 FTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEESRTVQGGVLQGWEMRLE 115

  Fly    64 TCKSKIAKKRPLRKQT-------------DTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHC 115
            | :..|.::..||.||             :...|.||.:.|:....|::|:|..:.....:|:..
Human   116 T-QWSILQQDFLRGQTSIGIQLEGKHNGRELCDCEQCGEVFSEHSCLKTHVRTQSTGNTHDCNQY 179

  Fly   116 SKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHL 180
            .|.|                   .:.|.||             .|||:..:..|....|:...::
Human   180 GKDF-------------------LTLCEKT-------------STGEKLSEFNQSEKIFSLTPNI 212

  Fly   181 QVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTH----------------------------QE 217
             |:.||.::|:.|||:||.|:|.|.|:||.|:|||                            ..
Human   213 -VYQRTSTQEKSFECSHCGKSFINESYLQAHMRTHNGEKLYEWRNYGPGFIDSTSLSVLIETLNA 276

  Fly   218 ARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHC 281
            .:|:||..|.|.::..:.|..|:.|| .|:.::|.:|.|.|..::|.|||.|.|.||.|:.|..|
Human   277 KKPYKCKECGKGYRYPAYLSIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHTGEKPYVCKEC 341

  Fly   282 SETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSH 346
            .:.|.:.|.|.:|:..|:|.:|.:|.:|..:|...|....|:|.||.|:.:.|.||.|:|...|:
Human   342 GKAFTQYSGLSMHVRSHSGDKPYECKECGKSFLTSSRLIQHIRTHTGEKPFVCVECGKAFAVSSN 406

  Fly   347 LVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHT 411
            |..|.:.||.|:..:|..|.|.|...:.|..||..|..:|...|..|.|.|..|:.|.:|::.||
Human   407 LSGHLRTHTEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCKECGKAFNYSTHLKIHMRIHT 471

  Fly   412 GKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSH 476
            |:..:||..|.|:::.||:..:|.||||||.|::|..|.|.|..|:..:.|.:|||.||||||..
Human   472 GEKPYECKQCGKAFSHSSSFQIHERTHTGEKPYECKECGKAFTCSSSFRIHEKTHTEEKPYKCQQ 536

  Fly   477 CSTRYTQKSSLGRH 490
            |...|:...||.||
Human   537 CGKAYSHPRSLRRH 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	141/445 (32%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		C2H2 Zn finger	167..187	CDD:275368	4/19 (21%)
		C2H2 Zn finger	195..215	CDD:275368	11/19 (58%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF426	NP_077011.1	KRAB	42..98	CDD:214630	9/46 (20%)
		C2H2 Zn finger	148..168	CDD:275368	7/19 (37%)
		C2H2 Zn finger	176..214	CDD:275368	11/70 (16%)
		zf-C2H2	224..246	CDD:395048	13/21 (62%)
		C2H2 Zn finger	226..246	CDD:275368	11/19 (58%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		zf-H2C2_2	294..319	CDD:463886	9/24 (38%)
		C2H2 Zn finger	310..330	CDD:275368	9/19 (47%)
		COG5048	<334..486	CDD:227381	53/151 (35%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		C2H2 Zn finger	422..442	CDD:275368	7/19 (37%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:463886	12/24 (50%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		zf-H2C2_2	518..543	CDD:463886	12/24 (50%)
		C2H2 Zn finger	534..554	CDD:275368	7/17 (41%)