DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and 9130019O22Rik

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_084502.2	Gene:	9130019O22Rik / 78921	MGIID:	1926171	Length:	543	Species:	Mus musculus

Alignment Length:	464	Identity:	154/464 - (33%)
Similarity:	213/464 - (45%)	Gaps:	95/464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 CKSKIAKKRPLRKQTD----TFK-------------------------------CTQCQKTFTRK 94
            |:.:..:||| |::|:    ||.                               |..|.|:|.|:
Mouse   101 CRHEKERKRP-REETEAMQKTFSPEPGQKEPQLSFAVSPSGVQATVLRADKCHDCNLCGKSFARR 164

  Fly    95 ENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHE 158
            ..||:|:..|..|:||:|..|:|.|||.:....|...|. :|||:|..|.|:|||.|.|..|::.
Mouse   165 STLEAHMYTHTGEKPFQCPDCNKRFGRYSSLSTHRAIHRGERPHQCPDCGKSFTQRSKLVAHMYT 229

  Fly   159 HTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKC 223
            ||||:||:|..|:..|:|.|.|..|...|..||..:|..|.|:|.....|..|:.:|...:||:|
Mouse   230 HTGEKPFQCPDCNKRFSRPSSLSTHRAIHRGERLHQCPDCGKSFTQRCTLVAHMYSHTGEKPFQC 294

  Fly   224 SHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFAR 287
            ..|:|.|...|.|..|...| .||..:|..|.|.|.|..:|..|:..|.||..|.||.|.::|.|
Mouse   295 PDCNKRFGRYSSLSSHRAIHRGERPHQCPDCGKGFTQRCTLVDHMYSHTGEKSFNCPDCCKSFGR 359

  Fly   288 NSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQ 352
            .|.|..|...|..::|.:||.|..||..||....|:|:||.|:.|.||:|.:.|.::|...|||:
Mouse   360 PSSLSRHRAIHRMEQPHRCSHCGRTFTRRSSLTSHLRVHTGEKPYCCADCGRCFSQRSAFREHQR 424

  Fly   353 -VHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQF 416
             ||:|..||.||
Mouse   425 VVHSGVTPFSCT----------------------------------------------------- 436

  Fly   417 ECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRY 481
               ||..::..|..|..|:|.||||.|:.|..|.:.|.:|:|...|.||||||:||.|..|..::
Mouse   437 ---HCGSAFADSKYLRRHMRIHTGEKPYSCPDCGRCFRQSSEIPAHRRTHTGERPYPCPQCGRQF 498

  Fly   482 TQKSSLGRH 490
            ..||::..|
Mouse   499 RTKSAMTSH 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/441 (33%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		C2H2 Zn finger	334..354	CDD:275368	8/20 (40%)
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		C2H2 Zn finger	390..410	CDD:275368	0/19 (0%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
9130019O22Rik	NP_084502.2	KRAB	22..81	CDD:214630
		KRAB	22..61	CDD:279668
		C2H2 Zn finger	154..174	CDD:275368	8/19 (42%)
		zf-H2C2_2	167..191	CDD:290200	11/23 (48%)
		C2H2 Zn finger	182..202	CDD:275368	7/19 (37%)
		zf-H2C2_2	194..219	CDD:290200	9/24 (38%)
		COG5048	206..>492	CDD:227381	121/341 (35%)
		C2H2 Zn finger	210..230	CDD:275368	9/19 (47%)
		zf-H2C2_2	223..247	CDD:290200	11/23 (48%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	279..303	CDD:290200	9/23 (39%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	9/24 (38%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-C2H2	376..398	CDD:278523	9/21 (43%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..455	CDD:275368	21/104 (20%)
		zf-H2C2_2	447..472	CDD:290200	11/24 (46%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		zf-H2C2_2	479..500	CDD:290200	11/20 (55%)
		C2H2 Zn finger	491..511	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000