DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF229

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_055333.3	Gene:	ZNF229 / 7772	HGNCID:	13022	Length:	825	Species:	Homo sapiens

Alignment Length:	539	Identity:	199/539 - (36%)
Similarity:	267/539 - (49%)	Gaps:	49/539 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDEPPQEDTFEEELIFISNSDFEEL----ESEIKI--------ENFCSYGKDLEP 54
            ||....:.|:|::..|.|.|.|.|...::.:..:.    |..:|.        :|.........|
Human   279 DLPPHPRVPLKEKLCQYDEFSEGLRHSAHLNRHQRVPTGEKSVKSLERGRGVRQNTHIRNHPRAP 343

  Fly    55 VKGVPSKLKTC------KSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECS 113
            |..:|.:...|      ||.:...:.:......:||.:|.|.|.|..||..|.|:|..|:|::||
Human   344 VGDMPYRCDVCGKGFRYKSVLLIHQGVHTGRRPYKCEECGKAFGRSSNLLVHQRVHTGEKPYKCS 408

  Fly   114 HCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARK 177
            .|.|.|...:..:.|...|. ::|:.||.|.|.|...|:|.:|.|.|.||:|:.|.:|...|:..
Human   409 ECGKGFSYSSVLQVHQRLHTGEKPYTCSECGKGFCAKSALHKHQHIHPGEKPYSCGECGKGFSCS 473

  Fly   178 SHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLT 242
            |||..|.:||:.|||::|..|.|.|.:||:||.|.|.|.....:||:.|.|||...|.|..|...
Human   474 SHLSSHQKTHTGERPYQCDKCGKGFSHNSYLQAHQRVHMGQHLYKCNVCGKSFSYSSGLLMHQRL 538

  Fly   243 H-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKC 306
            | .|:.:|| :|.|:|.::..|.||.|||.||.|:||..|.:.|.|||.|..|...|.|:.|..|
Human   539 HTGEKPYKC-ECGKSFGRSSDLHIHQRVHTGEKPYKCSECGKGFRRNSDLHSHQRVHTGERPYVC 602

  Fly   307 SQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKC 371
            ..|...|...|...:|.|:||.|:.||||||.|.|...|.|:.||:|||||:|::|..|.|.|:|
Human   603 DVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFSYSSGLLIHQRVHTGEKPYRCQECGKGFRC 667

  Fly   372 --------RTH--------------------LRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQ 408
                    |.|                    ||.|...|.|||...|..|.|.|:..|.||.|.:
Human   668 TSSLHKHQRVHTGKKPYTCDQCGKGFSYGSNLRTHQRLHTGEKPYTCCECGKGFRYGSGLLSHKR 732

  Fly   409 EHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYK 473
            .|||:..:.|..|.|.|:.||.|..|.|.||||.|:||..|.|.|.|::....|.|.|||||||.
Human   733 VHTGEKPYRCHVCGKGYSQSSHLQGHQRVHTGEKPYKCEECGKGFGRNSCLHVHQRVHTGEKPYT 797

  Fly   474 CSHCSTRYTQKSSLGRHLR 492
            |..|...::..|.|..|.|
Human   798 CGVCGKGFSYTSGLRNHQR 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	176/433 (41%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	10/47 (21%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		KRAB	34..>74	CDD:214630
		KRAB	34..73	CDD:279668
		C2H2 Zn finger	351..371	CDD:275368	3/19 (16%)
		COG5048	375..787	CDD:227381	166/412 (40%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		zf-H2C2_2	420..442	CDD:290200	7/21 (33%)
		C2H2 Zn finger	435..455	CDD:275368	9/19 (47%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		zf-H2C2_2	475..500	CDD:290200	12/24 (50%)
		C2H2 Zn finger	491..511	CDD:275368	10/19 (53%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		C2H2 Zn finger	547..566	CDD:275368	8/19 (42%)
		zf-H2C2_2	562..583	CDD:290200	11/20 (55%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		zf-H2C2_2	589..611	CDD:290200	7/21 (33%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		zf-H2C2_2	614..639	CDD:290200	13/24 (54%)
		C2H2 Zn finger	630..650	CDD:275368	10/19 (53%)
		zf-H2C2_2	643..667	CDD:290200	13/23 (57%)
		C2H2 Zn finger	658..678	CDD:275368	6/19 (32%)
		zf-H2C2_2	673..695	CDD:290200	2/21 (10%)
		C2H2 Zn finger	686..706	CDD:275368	3/19 (16%)
		zf-H2C2_2	698..723	CDD:290200	11/24 (46%)
		C2H2 Zn finger	714..734	CDD:275368	8/19 (42%)
		zf-H2C2_2	727..751	CDD:290200	10/23 (43%)
		C2H2 Zn finger	742..762	CDD:275368	9/19 (47%)
		zf-H2C2_2	754..779	CDD:290200	13/24 (54%)
		C2H2 Zn finger	770..790	CDD:275368	7/19 (37%)
		zf-H2C2_2	785..807	CDD:290200	11/21 (52%)
		C2H2 Zn finger	798..818	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900