Protein Alignment CG5245 and ZNF226

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_057528.2
• Gene: ZNF226 / 7769
• HGNCID: 13019
• Length: 803
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 188/450 - (41%)
• Similarity: 266/450 - (59%)
• Gaps: 9/450 - (2%)

  Fly    59 PSKLKTCKSKIAKKRPLRKQTDT------FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSK 117
            |.|.|.|....:::..|......      :.|.:|.:.|::..:|:.|.|||..|:||:|..|.|
Human   334 PYKCKQCGKGFSRRSALNVHCKVHTAEKPYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGK 398

  Fly   118 SFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQ 181
            ||.|.:|.:.|...|. ::|:||..|.|.|..:|:|..|...||||:|:||.:|...|:|.|.||
Human   399 SFSRNSHLQSHQRVHTGEKPYKCEECGKGFICSSNLYIHQRVHTGEKPYKCEECGKGFSRPSSLQ 463

  Fly   182 VHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AE 245
            .|...|:.|:.:.||.|.|.|..:|:||.|.|.|...:|:||:.|.|||:..|..|.||:.| .|
Human   464 AHQGVHTGEKSYICTVCGKGFTLSSNLQAHQRVHTGEKPYKCNECGKSFRRNSHYQVHLVVHTGE 528

  Fly   246 RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCS 310
            :.:||..|.|.|.|:..||||.:.|:.|.||||..|.:.|.::||||:|.|.|.|::|.||.:|.
Human   529 KPYKCEICGKGFSQSSYLQIHQKAHSIEKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECG 593

  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375
            ..|:.|:..::|.|:||.|:.|.|.||.|.|.:.|:|:.||:||:||:||||..|.|.|....||
Human   594 KGFSRRADLKIHCRIHTGEKPYNCEECGKVFRQASNLLAHQRVHSGEKPFKCEECGKSFGRSAHL 658

  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440
            :.|...|.|:|..||..|.|.||.|..|.:|.:.|||:..::|..|.|.::.:|:|.:|...|||
Human   659 QAHQKVHTGDKPYKCDECGKGFKWSLNLDMHQRVHTGEKPYKCGECGKYFSQASSLQLHQSVHTG 723

  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTKS 500
            |.|:||..|.|:|:||::.|.|.|.|||||||||..|...::.:|:|..| .|...|.||
Human   724 EKPYKCDVCGKVFSRSSQLQSHQRVHTGEKPYKCEICGKSFSWRSNLTVH-HRIHVGDKS 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	176/411 (43%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF226	NP_057528.2	KRAB	8..67	CDD:214630
		C2H2 Zn finger	256..302	CDD:275370
		SUF4-like	306..>357	CDD:411020	5/22 (23%)
		C2H2 Zn finger	309..334	CDD:411020	187/449 (42%)
		C2H2 Zn finger	309..329	CDD:275368
		C2H2 Zn finger	337..357	CDD:411020	3/19 (16%)
		C2H2 Zn finger	337..357	CDD:275368	3/19 (16%)
		COG5048	359..774	CDD:227381	179/415 (43%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	10/19 (53%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		C2H2 Zn finger	533..553	CDD:275368	9/19 (47%)
		C2H2 Zn finger	561..581	CDD:275368	9/19 (47%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		C2H2 Zn finger	617..637	CDD:275368	9/19 (47%)
		C2H2 Zn finger	645..665	CDD:275368	7/19 (37%)
		C2H2 Zn finger	673..693	CDD:275368	8/19 (42%)
		C2H2 Zn finger	701..721	CDD:275368	6/19 (32%)
		C2H2 Zn finger	729..749	CDD:275368	9/19 (47%)
		C2H2 Zn finger	757..777	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	781..803		1/1 (100%)