DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF223

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_037493.3	Gene:	ZNF223 / 7766	HGNCID:	13016	Length:	482	Species:	Homo sapiens

Alignment Length:	494	Identity:	147/494 - (29%)
Similarity:	217/494 - (43%)	Gaps:	86/494 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKT----------- 64
            |..:|...|||.    |:....|..::...:.|.  :.|..::|      ::||
Human    47 VGHQPFHRDTFH----FLREEKFWMMDIATQREG--NSGGKIQP------EMKTFPEAGPHEGWS 99

  Fly    65 CK---SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLR-LHAEERPFECSHCSKSFGRRTHY 125
            |:   .:||... .|.|..|.|.:|..:.......:|..|. :|..::|..|..|.:||...:.:
Human   100 CQQIWEEIASDL-TRPQDSTIKSSQFFEQGDAHSQVEEGLSIMHTGQKPSNCGKCKQSFSDMSIF 163

  Fly   126 K-RHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSE 189
            . ...::..::.|.|..|.|:|...|:|..|...|.||:.|||..|...|::..|||.|.|.|:.
Human   164 DLPQQIRSAEKSHSCDECGKSFCYISALHIHQRVHLGEKLFKCDVCGKEFSQSLHLQTHQRVHTG 228

  Fly   190 ERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQC 253
            |                            :||||..|.:.|:.||.|..|...| .|:.:.|..|
Human   229 E----------------------------KPFKCEQCGRGFRCRSALTVHCKLHMGEKHYNCEAC 265

  Fly   254 PKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSL 318
            .:.|:.:..||.|.|:|.||.||||..||.:|...|.|..|.:.|.||:|....:....|..|..
Human   266 GRAFIHDFQLQKHQRIHTGEKPFKCEICSVSFRLRSSLNRHCVVHTGKKPNSTGEYGKGFIRRLD 330

  Fly   319 YRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHI 383
            ...|..:||.|:.|.|.||.|||.:.|:|:.||:|||||:|:||..|.|
Human   331 LCKHQTIHTGEKPYNCKECGKSFRRSSYLLIHQRVHTGEKPYKCDKCGK---------------- 379

  Fly   384 GEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSH 448
                   ||.:|     |.|.:|.:.|||:..:.|..|.||:..:|::..|.|.|..:.||||..
Human   380 -------SYITK-----SGLDLHHRAHTGERPYNCDDCGKSFRQASSILNHKRLHCRKKPFKCED 432

  Fly   449 CSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSL 487
            |.|.....:..::..:.|:||.|.||..|..||.::.:|
Human   433 CGKKLVYRSYRKDQQKNHSGENPSKCEDCGKRYKRRLNL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	128/406 (32%)
		C2H2 Zn finger	84..104	CDD:275368	3/20 (15%)
		C2H2 Zn finger	112..132	CDD:275368	4/20 (20%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	7/24 (29%)
		C2H2 Zn finger	195..215	CDD:275368	0/19 (0%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	3/19 (16%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	3/19 (16%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	3/19 (16%)
		C2H2 Zn finger	474..492	CDD:275368	5/14 (36%)
ZNF223	NP_037493.3	KRAB	8..67	CDD:214630	7/23 (30%)
		KRAB	8..47	CDD:279668	147/494 (30%)
		COG5048	<139..380	CDD:227381	92/291 (32%)
		C2H2 Zn finger	150..170	CDD:275368	4/19 (21%)
		C2H2 Zn finger	178..198	CDD:275368	7/19 (37%)
		C2H2 Zn finger	206..226	CDD:275368	8/19 (42%)
		zf-H2C2_2	218..243	CDD:290200	13/52 (25%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		zf-H2C2_2	275..297	CDD:290200	13/21 (62%)
		C2H2 Zn finger	294..310	CDD:275370	5/15 (33%)
		C2H2 Zn finger	322..338	CDD:275368	3/15 (20%)
		zf-H2C2_2	333..355	CDD:290200	11/21 (52%)
		C2H2 Zn finger	346..366	CDD:275368	10/19 (53%)
		zf-H2C2_2	358..383	CDD:290200	15/47 (32%)
		C2H2 Zn finger	374..394	CDD:275368	9/47 (19%)
		C2H2 Zn finger	402..422	CDD:275368	7/19 (37%)
		C2H2 Zn finger	430..450	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900