DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF195

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001123992.1	Gene:	ZNF195 / 7748	HGNCID:	12986	Length:	629	Species:	Homo sapiens

Alignment Length:	490	Identity:	161/490 - (32%)
Similarity:	220/490 - (44%)	Gaps:	38/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PPQ--EDTFEEELI----------FISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKS 67
            |.|  :|.|.:.::          .....|:|.|:.       |...||   ..|:.....|..|
Human   159 PEQGIQDAFPKRILRGYGNCGLDNLYLRKDWESLDE-------CKLQKD---YNGLNQCSSTTHS 213

  Fly    68 KIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKH 132
            ||            |:..:..|.|....||......:..|:||:|..|.|||...:....|...|
Human   214 KI------------FQYNKYVKIFDNFSNLHRRNISNTGEKPFKCQECGKSFQMLSFLTEHQKIH 266

  Fly   133 E-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECT 196
            . |:..||..|.|||.|.|...:..:..|||:|:||.:|:......|.|..: |.::....:.|.
Human   267 TGKKFQKCGECGKTFIQCSHFTEPENIDTGEKPYKCQECNNVIKTCSVLTKN-RIYAGGEHYRCE 330

  Fly   197 HCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSF-KLRSILQKHLLTHAERSFKCTQCPKTFLQN 260
            ...|.|...|||.||....:| :|.|...||..| ...|:..:.::...|:..||....|.|..:
Human   331 EFGKVFNQCSHLTEHEHGTEE-KPCKYEECSSVFISCSSLSNQQMILAGEKLSKCETWYKGFNHS 394

  Fly   261 DSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRL 325
            .:...|.|...|..||||..|...|...|.|..|...|.|::|.||.:|...:...|....|.|:
Human   395 PNPSKHQRNEIGGKPFKCEECDSIFKWFSDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSEHRRI 459

  Fly   326 HTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKC 390
            ||.|:.|:|.||.|.|...|.|..|::.|:.|:|:.|..|...||..:.|..|...|.|||..||
Human   460 HTGEKPYQCEECGKVFRTCSSLSNHKRTHSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKC 524

  Fly   391 SYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFAR 455
            ..|.|.|..||.|:||.:.|||:..::|..|.:.:...|.:..|.:|||||.|:||..|.|.|.:
Human   525 DECGKNFTQSSNLIVHKRIHTGEKPYKCEECGRVFMWFSDITKHKKTHTGEKPYKCDECGKNFTQ 589

  Fly   456 SAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |:....|.|.|||||||||..|...:||.|.|..|
Human   590 SSNLIVHKRIHTGEKPYKCEKCGKAFTQFSHLTVH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	140/405 (35%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		zf-H2C2_2	179..204	CDD:290200	5/24 (21%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	4/20 (20%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	4/19 (21%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF195	NP_001123992.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		Spacer	76..243		21/105 (20%)
		COG5048	225..629	CDD:227381	144/402 (36%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		C2H2 Zn finger	302..345	CDD:275368	11/43 (26%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		zf-H2C2_2	424..449	CDD:290200	8/24 (33%)
		C2H2 Zn finger	440..460	CDD:275368	5/19 (26%)
		zf-H2C2_2	452..477	CDD:290200	11/24 (46%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..505	CDD:290200	8/24 (33%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		zf-H2C2_2	508..533	CDD:290200	11/24 (46%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..559	CDD:290200	8/22 (36%)
		C2H2 Zn finger	552..572	CDD:275368	4/19 (21%)
		zf-H2C2_2	567..589	CDD:290200	12/21 (57%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		zf-H2C2_2	592..617	CDD:290200	12/24 (50%)
		C2H2 Zn finger	608..628	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900