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Protein Alignment CG5245 and ZNF189

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003443.2	Gene:	ZNF189 / 7743	HGNCID:	12980	Length:	626	Species:	Homo sapiens

Alignment Length:	551	Identity:	194/551 - (35%)
Similarity:	280/551 - (50%)	Gaps:	78/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLANVDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIK-------------------IENFC 46
            :|:.|.|    |||.|   |.::|:        ||:|.|::                   .|.|.
Human    53 LDVLNRD----KDEEP---TVKQEI--------EEIEEEVEPQGVIVTRIKSEIDQDPMGRETFE 102

  Fly    47 SYGKDLEPVKG-----VPSKLKTCKSK-------IAKKRPLRKQTDTFKCTQCQKTFTRKENLES 99
            ..|: |:..:|     :|.:..|.:.:       |.:||| ..:....||.:|.|.|.||.:...
Human   103 LVGR-LDKQRGIFLWEIPRESLTQEQRMFRENTNIIRKRP-NSEEKCHKCEECGKGFVRKAHFIQ 165

  Fly   100 HLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGER 163
            |.|:|..|:||:|:.|.|||.|.:....|...|. :||::|::|.|||:.:|:|.:|...|||||
Human   166 HQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGER 230

  Fly   164 PFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSK 228
            |::|.||..||:::..|..|.|.|:.|:|.:|:.|.|||...|||.||.|||...:|:.|:.|.|
Human   231 PYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKK 295

  Fly   229 SFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQ 292
            ||...|:|.:|...| .||..||.:|.|.|..:..|..|.::|.||.||.|..|.::|:|:|.|.
Human   296 SFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLI 360

  Fly   293 LHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHT-- 355
            .|...|.|:.|.:|.:|..:|:.......|.|:||.::.:||.||.|:|.:.|.|::||::||
Human   361 EHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTRE 425

  Fly   356 --------------------------GERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCS 394
                                      .|:.:||..|.|.|....||..|...|.|||...|:.|.
Human   426 KTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCG 490

  Fly   395 KEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEH 459
            |.|..||.|:.|.:.|||:..:.|..|.||::....|..|...|||..|.||..|.|.|:|::..
Human   491 KSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGL 555

  Fly   460 QEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            .:|.|.|||||||||..|...::|:.||..|
Human   556 IQHQRIHTGEKPYKCEKCDKSFSQQRSLVNH 586

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.