DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF180

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens

Alignment Length:	439	Identity:	167/439 - (38%)
Similarity:	246/439 - (56%)	Gaps:	28/439 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KIENFCSYGKDL---EPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLR 102
            :|::|| :|..|   |.:.|                    ...||...:|.:....|.:.....|
Human   278 RIQSFC-HGTPLHIHEKIHG--------------------GGKTFDFKECGQVLNPKISHNEQQR 321

  Fly   103 LHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKC 167
            :..||..::||..|.|.....:.:.:   .|::|.:|:.|.|:|:.:|.|..|...||||:|::|
Human   322 IPFEESQYKCSETSHSSSLTQNMRNN---SEEKPFECNQCGKSFSWSSHLVAHQRTHTGEKPYEC 383

  Fly   168 TQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKL 232
            ::|..||:|.|||..|.|||:.|:|:.|..|.|:|..:..|..|.|||...:|::|:.|.|||:.
Human   384 SECGKSFSRSSHLVSHQRTHTGEKPYRCNQCGKSFSQSYVLVVHQRTHTGEKPYECNQCGKSFRQ 448

  Fly   233 RSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLL 296
            ...|..|..|| .|:.::|.||.|:|:|:..|..|.|:|.||.|::|..|.::|:::.:|..|..
Human   449 SYKLIAHQRTHTGEKPYECNQCGKSFIQSYKLIAHQRIHTGEKPYECNQCGKSFSQSYKLVAHQR 513

  Fly   297 EHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFK 361
            .|.|::|.:|:||..:|:..|....|.|.||.|:.|:|:||.|||.:.||||.||::||||:|::
Human   514 THTGEKPFECNQCGKSFSWSSQLVAHQRTHTGEKPYECSECGKSFNRSSHLVMHQRIHTGEKPYE 578

  Fly   362 CTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYT 426
            |..|.|.|.....|.||...|.|||..:||.|.|.|:.||.|..|.:.|||:..|||..|.|:::
Human   579 CNQCGKSFSQSYVLVVHQRTHTGEKPYECSQCGKSFRQSSCLTQHQRTHTGEKPFECNQCGKTFS 643

  Fly   427 TSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCS 475
            .|:.|.:|.||||||.||.|..|.|.|..|.:...|..|||.||.|:|:
Human   644 LSARLIVHQRTHTGEKPFTCIQCGKAFINSYKLIRHQATHTEEKLYECN 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	160/403 (40%)
		C2H2 Zn finger	84..104	CDD:275368	3/19 (16%)
		C2H2 Zn finger	112..132	CDD:275368	4/19 (21%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	12/19 (63%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	1/2 (50%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630
		KRAB	72..111	CDD:279668
		C2H2 Zn finger	249..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368	6/17 (35%)
		COG5048	332..692	CDD:227381	151/362 (42%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..392	CDD:290200	11/24 (46%)
		C2H2 Zn finger	383..403	CDD:275368	10/19 (53%)
		zf-H2C2_2	395..420	CDD:290200	12/24 (50%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		zf-H2C2_2	424..448	CDD:290200	11/23 (48%)
		C2H2 Zn finger	439..459	CDD:275368	7/19 (37%)
		zf-H2C2_2	455..476	CDD:290200	9/20 (45%)
		C2H2 Zn finger	467..487	CDD:275368	9/19 (47%)
		zf-H2C2_2	483..504	CDD:290200	9/20 (45%)
		C2H2 Zn finger	495..515	CDD:275368	5/19 (26%)
		zf-H2C2_2	508..531	CDD:290200	8/22 (36%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..560	CDD:290200	12/23 (52%)
		C2H2 Zn finger	551..571	CDD:275368	12/19 (63%)
		zf-H2C2_2	563..588	CDD:290200	14/24 (58%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	592..616	CDD:290200	12/23 (52%)
		C2H2 Zn finger	607..627	CDD:275368	9/19 (47%)
		zf-H2C2_2	620..643	CDD:290200	10/22 (45%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		zf-H2C2_2	648..670	CDD:290200	13/21 (62%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910