DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5245 and ZNF177

DIOPT Version :9

Sequence 1:NP_650197.1 Gene:CG5245 / 41530 FlyBaseID:FBgn0038047 Length:501 Species:Drosophila melanogaster
Sequence 2:NP_001166122.1 Gene:ZNF177 / 7730 HGNCID:12966 Length:481 Species:Homo sapiens


Alignment Length:485 Identity:160/485 - (32%)
Similarity:240/485 - (49%) Gaps:55/485 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 TFEEELIFISNSDF-------EELESEIKIENF---CSYGKDLEPVKGVPSKLKTCK-SKIAKKR 73
            ||:|..:..|..::       :.|..::.:|||   .|.|..|            |: |.|:|..
Human    15 TFQEVAVDFSQEEWALLDPAQKNLYKDVMLENFRNLASVGYQL------------CRHSLISKVD 67

  Fly    74 PLRKQTD-----TFKCTQCQKTFTRKENL---------ESHLRLHAEERP----FECSHCSKSFG 120
            ..:.:||     ...|...:.....|:.:         .|:....||.:|    .||:||.| |.
Human    68 QEQLKTDERGILQGDCADWETQLKPKDTIAMQNIPGGKTSNGINTAENQPGEHSLECNHCGK-FR 131

  Fly   121 RRTHY--KRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVH 183
            :.|.:  .|: .|.|| .:|....||.|...|:|:.|:..|.||:..:.|.|..:|.::|.|:.|
Human   132 KNTRFICTRY-CKGEK-CYKYIKYSKVFNHPSTLRSHVSIHIGEKTLEFTDCRKAFNQESSLRKH 194

  Fly   184 LRTHSEERPFECTHCEKAFKNNS--HLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLT-HAE 245
            |||.:.::..|...|:.:|..:|  .::|.:.|.:     |...||...|: |.|..|..| ..|
Human   195 LRTPTGQKFQEYEQCDMSFSLHSSCSVREQIPTGE-----KGDECSDYGKI-SPLSVHTKTGSVE 253

  Fly   246 RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCS 310
            ...:|.:..|||....|||..:|.|:||.|::|..|.:.|...|.|:.|:..|.|::|.:|..|.
Human   254 EGLECNEHEKTFTDPLSLQNCVRTHSGEMPYECSDCGKAFIFQSSLKKHMRSHTGEKPYECDHCG 318

  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375
            .:|:..|...||.|.||.|:.|.|.||.|:|...|.|.:|.:.||||:|::|:.|.|.|..::.|
Human   319 KSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCGKAFIDQSSL 383

  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440
            :.|...|.|||..:|:.|.|.|...|.|:||.:.|||:..:||..|.|::..||.|.:|:|||||
Human   384 KKHTRSHTGEKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCLRVHVRTHTG 448

  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEK 470
            |.|:||..|.|.|:.|.....|.|.|.|:|
Human   449 EKPYKCIQCEKAFSTSTNLIMHKRIHNGQK 478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5245NP_650197.1 COG5048 74..478 CDD:227381 145/420 (35%)
C2H2 Zn finger 84..104 CDD:275368 3/28 (11%)
C2H2 Zn finger 112..132 CDD:275368 7/21 (33%)
C2H2 Zn finger 139..159 CDD:275368 6/19 (32%)
C2H2 Zn finger 167..187 CDD:275368 8/19 (42%)
zf-H2C2_2 179..204 CDD:290200 8/24 (33%)
C2H2 Zn finger 195..215 CDD:275368 4/21 (19%)
C2H2 Zn finger 223..243 CDD:275368 7/20 (35%)
C2H2 Zn finger 250..270 CDD:275368 8/19 (42%)
C2H2 Zn finger 278..298 CDD:275368 6/19 (32%)
C2H2 Zn finger 306..326 CDD:275368 7/19 (37%)
C2H2 Zn finger 334..354 CDD:275368 8/19 (42%)
C2H2 Zn finger 362..382 CDD:275368 6/19 (32%)
C2H2 Zn finger 390..410 CDD:275368 8/19 (42%)
C2H2 Zn finger 418..438 CDD:275368 8/19 (42%)
C2H2 Zn finger 446..466 CDD:275368 7/19 (37%)
C2H2 Zn finger 474..492 CDD:275368
ZNF177NP_001166122.1 KRAB 14..70 CDD:214630 15/66 (23%)
C2H2 Zn finger 124..142 CDD:275368 7/19 (37%)
C2H2 Zn finger 150..170 CDD:275368 6/19 (32%)
C2H2 Zn finger 178..197 CDD:275368 7/18 (39%)
COG5048 <212..442 CDD:227381 86/235 (37%)
C2H2 Zn finger 258..278 CDD:275368 8/19 (42%)
C2H2 Zn finger 286..306 CDD:275368 6/19 (32%)
C2H2 Zn finger 314..334 CDD:275368 7/19 (37%)
C2H2 Zn finger 342..362 CDD:275368 8/19 (42%)
C2H2 Zn finger 370..390 CDD:275368 6/19 (32%)
C2H2 Zn finger 398..418 CDD:275368 8/19 (42%)
C2H2 Zn finger 426..446 CDD:275368 8/19 (42%)
zf-H2C2_2 439..463 CDD:404364 14/23 (61%)
C2H2 Zn finger 454..474 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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