DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF157

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003437.2	Gene:	ZNF157 / 7712	HGNCID:	12942	Length:	506	Species:	Homo sapiens

Alignment Length:	418	Identity:	151/418 - (36%)
Similarity:	218/418 - (52%)	Gaps:	63/418 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 CKSKIAKKRPL--RKQT----DTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRT 123
            |:....:|...  ||:|    ..|:|.:|.|.:.||.||..|||:|..|||:||..|:|:|..|:
Human   139 CRKAFHEKTGFVRRKRTPRGDKNFECHECGKAYCRKSNLVEHLRIHTGERPYECGECAKTFSARS 203

  Fly   124 HYKRHLLKHEKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHS 188
                :|:.|:|                       .|||||||:|.:|..||.|||.|.:|.|||:
Human   204 ----YLIAHQK-----------------------THTGERPFECNECGKSFGRKSQLILHTRTHT 241

  Fly   189 EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQ 252
            .|||:|||.|.|.|...:.|..|.|||...:|::||.|.|:|:::..|.:|..|| .|:.::|.:
Human   242 GERPYECTECGKTFSEKATLTIHQRTHTGEKPYECSECGKTFRVKISLTQHHRTHTGEKPYECGE 306

  Fly   253 CPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRS 317
            |.|.|....||..|.|:|.||.|::|..|.:.|.....|..|...|.|::|.:|::|..:|.:.|
Human   307 CGKNFRAKKSLNQHQRIHTGEKPYECGECGKFFRMKMTLNNHQRTHTGEKPYQCNECGKSFRVHS 371

  Fly   318 LYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDH 382
            ...:|.|:||.|:.|:|.||..:|:.|:.|:|||::|:||:|:
Human   372 SLGIHQRIHTGEKPYECNECGNAFYVKARLIEHQRMHSGEKPY---------------------- 414

  Fly   383 IGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCS 447
                  :||.|.|.|.:...|..|.:.|||:..:||..|..::.....|..|.|.||||.||:|.
Human   415 ------ECSECGKIFSMKKSLCQHRRTHTGEKPYECSECGNAFYVKVRLIEHQRIHTGERPFECQ 473

  Fly   448 HCSKLFARSAEHQEHLRTHTGEKPYKCS 475
            .|.|.|.|.|...||.|||.|.. ::|:
Human   474 ECGKAFCRKAHLTEHQRTHIGWS-WRCT 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	149/409 (36%)
		C2H2 Zn finger	84..104	CDD:275368	10/19 (53%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	0/19 (0%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	14/24 (58%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	0/19 (0%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	1/2 (50%)
ZNF157	NP_003437.2	KRAB	27..87	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	137..156	CDD:275368	4/16 (25%)
		COG5048	159..499	CDD:227381	145/395 (37%)
		C2H2 Zn finger	164..184	CDD:275368	10/19 (53%)
		zf-H2C2_2	176..200	CDD:290200	13/23 (57%)
		C2H2 Zn finger	192..212	CDD:275368	8/46 (17%)
		zf-H2C2_2	204..229	CDD:290200	14/47 (30%)
		C2H2 Zn finger	220..240	CDD:275368	10/19 (53%)
		zf-H2C2_2	236..256	CDD:290200	12/19 (63%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		zf-H2C2_2	261..283	CDD:290200	10/21 (48%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..311	CDD:290200	8/22 (36%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-H2C2_2	316..339	CDD:290200	10/22 (45%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	345..367	CDD:290200	7/21 (33%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..395	CDD:290200	9/22 (41%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	401..424	CDD:290200	12/50 (24%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..451	CDD:290200	7/19 (37%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		zf-H2C2_2	457..479	CDD:290200	12/21 (57%)
		zf-C2H2	470..492	CDD:278523	10/21 (48%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910