DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF132

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003424.3	Gene:	ZNF132 / 7691	HGNCID:	12916	Length:	706	Species:	Homo sapiens

Alignment Length:	464	Identity:	174/464 - (37%)
Similarity:	252/464 - (54%)	Gaps:	36/464 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTC------KSKIAKKRP 74
            |....|.||...:.|..|...|                    :|...|.|      .||:.|.:.
Human   267 PTGGNFLEEKSILGNKKFHTGE--------------------IPHVCKECGKAFSHSSKLRKHQK 311

  Fly    75 LRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHEK----- 134
            ...:...::|..|.|||..|.....|.|:|:.|||:||..|.|:|..|:    ||::|||
Human   312 FHTEVKYYECIACGKTFNHKLTFVHHQRIHSGERPYECDECGKAFSNRS----HLIRHEKVHTGE 372

  Fly   135 RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCE 199
            ||.:|..|.:.|:|:|:..:|...||..||::|:||..||:|.|.|..|.|.|:.|||:||:.|.
Human   373 RPFECLKCGRAFSQSSNFLRHQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECG 437

  Fly   200 KAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSL 263
            :||.|||:|.:|.:.|...|||:||.|.:.|...|.|.:|...| .||.|:|..|.|.|..:.:|
Human   438 RAFNNNSNLAQHQKVHTGERPFECSECGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTL 502

  Fly   264 QIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTR 328
            ..|.:||.|:.|::|..|.::|:|:|.|..|...|.|::|.:||:|...||..|....|.|:||:
Human   503 IQHQKVHTGQRPYECSECRKSFSRSSSLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHTK 567

  Fly   329 ERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYC 393
            ||.|:|.||.|.|.:.|.|::||:|||||:|:||:.|.|.|..::.|..|...|.||:..:||.|
Human   568 ERPYECNECGKFFSQNSILIKHQKVHTGEKPYKCSECGKFFSRKSSLICHWRVHTGERPYECSEC 632

  Fly   394 SKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAE 458
            .:.|..:|.|:.|.:.||.:..:||..|.|:::..|||..|.:.||.|..::||.|.|||:....
Human   633 GRAFSSNSHLVRHQRVHTQERPYECIQCGKAFSERSTLVRHQKVHTRERTYECSQCGKLFSHLCN 697

  Fly   459 HQEHLRTHT 467
            ..:|.:.||
Human   698 LAQHKKIHT 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/400 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF132	NP_003424.3	KRAB	37..78	CDD:307490
		COG5048	105..528	CDD:227381	101/284 (36%)
		C2H2 Zn finger	116..136	CDD:275368
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	238..285	CDD:275368	5/17 (29%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		C2H2 Zn finger	349..369	CDD:275368	10/23 (43%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		COG5048	383..>706	CDD:227381	132/322 (41%)
		C2H2 Zn finger	405..425	CDD:275368	10/19 (53%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	573..593	CDD:275368	9/19 (47%)
		C2H2 Zn finger	601..621	CDD:275368	6/19 (32%)
		C2H2 Zn finger	629..649	CDD:275368	7/19 (37%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		C2H2 Zn finger	685..705	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900