DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF90

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_009069.1	Gene:	ZNF90 / 7643	HGNCID:	13165	Length:	601	Species:	Homo sapiens

Alignment Length:	503	Identity:	182/503 - (36%)
Similarity:	259/503 - (51%)	Gaps:	29/503 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EPPQEDTFEEELIFISNSDFEELE-SEIKIENFC-----------SYGKDLEPVKGVPSKLKTCK 66
            |...:|:|::.::    :.:|:.| ..::::..|           .|....:.:....||:..|.
Human    88 EQSLKDSFQKVIV----TRYEKREYGNLELKKGCESVDEGKVHKRGYNGLNQCLTATQSKVFQCD 148

  Fly    67 -----SKIAKKRPLRKQTDT----FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRR 122
                 |.|.......|..||    |||.:|.|.|.:...|.:|.::|..|...:|..|.|:|.|.
Human   149 TYVKVSHIFSNSNRHKIRDTGKKPFKCIECGKAFNQSSTLATHKKIHTGEITCKCEECGKAFNRS 213

  Fly   123 THYKRHLLKH--EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLR 185
            :|...|...|  ||| :||..|.|....:|:|..|...||||:.:||..|.......|.|..|.|
Human   214 SHLTSHKRIHTGEKR-YKCEDCGKELKYSSTLTAHKRIHTGEKRYKCEDCGKELKYSSTLTAHKR 277

  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFK 249
            .|:.|:|::|..|.:||.::|.|..|..:|.|.:|:||..|.|:|||.|||..|...| .|:.:|
Human   278 IHTGEKPYKCDKCGRAFISSSILYVHKISHTEEKPYKCEECGKAFKLSSILSTHKRIHTGEKPYK 342

  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314
            |.:|.|.|.::..|:.|.|:|.||.|:||..|.:.|..:|.|..|.:.|:.|:|.||.:|...|.
Human   343 CEECGKAFRRSLVLRTHKRIHTGEKPYKCDKCGKAFISSSLLYKHKISHSEKKPYKCEECGKAFK 407

  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379
            ..|...:|...||.|:.|||.||.|.|.:.|.|..|:.:|:||:|:||..|.|.||..::|..|.
Human   408 RSSTLTIHKISHTEEKPYKCQECDKVFKRSSALSTHKIIHSGEKPYKCEECGKAFKRSSNLTTHK 472

  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444
            :.|..||:.||..|.|.||.||.|..|...|:|:|.::|..|.|::..||.|..|...|||..|:
Human   473 ISHTEEKLYKCQECDKAFKYSSALSTHKIIHSGENPYKCEECGKAFKRSSVLSKHKIIHTGAKPY 537

  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            ||..|.|.|.||::...|..:|||||||||..|...:...|.|..|.|
Human   538 KCEECGKAFKRSSQLTSHKISHTGEKPYKCEECGKAFNLSSDLNTHKR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	165/410 (40%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF90	NP_009069.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		COG5048	170..501	CDD:227381	131/331 (40%)
		C2H2 Zn finger	175..195	CDD:275368	6/19 (32%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..296	CDD:290200	10/23 (43%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		zf-H2C2_2	300..323	CDD:290200	9/22 (41%)
		C2H2 Zn finger	315..335	CDD:275368	10/19 (53%)
		zf-H2C2_2	328..352	CDD:290200	9/23 (39%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		zf-H2C2_2	356..380	CDD:290200	11/23 (48%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		zf-H2C2_2	495..520	CDD:290200	8/24 (33%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		zf-H2C2_2	524..548	CDD:290200	11/23 (48%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		zf-H2C2_2	552..575	CDD:290200	11/22 (50%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810