Protein Alignment CG5245 and ZNF90

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_009069.1
• Gene: ZNF90 / 7643
• HGNCID: 13165
• Length: 601
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 182/503 - (36%)
• Similarity: 259/503 - (51%)
• Gaps: 29/503 - (5%)

  Fly    14 EPPQEDTFEEELIFISNSDFEELE-SEIKIENFC-----------SYGKDLEPVKGVPSKLKTCK 66
            |...:|:|::.::    :.:|:.| ..::::..|           .|....:.:....||:..|.
Human    88 EQSLKDSFQKVIV----TRYEKREYGNLELKKGCESVDEGKVHKRGYNGLNQCLTATQSKVFQCD 148

  Fly    67 -----SKIAKKRPLRKQTDT----FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRR 122
                 |.|.......|..||    |||.:|.|.|.:...|.:|.::|..|...:|..|.|:|.|.
Human   149 TYVKVSHIFSNSNRHKIRDTGKKPFKCIECGKAFNQSSTLATHKKIHTGEITCKCEECGKAFNRS 213

  Fly   123 THYKRHLLKH--EKRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLR 185
            :|...|...|  ||| :||..|.|....:|:|..|...||||:.:||..|.......|.|..|.|
Human   214 SHLTSHKRIHTGEKR-YKCEDCGKELKYSSTLTAHKRIHTGEKRYKCEDCGKELKYSSTLTAHKR 277

  Fly   186 THSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFK 249
            .|:.|:|::|..|.:||.::|.|..|..:|.|.:|:||..|.|:|||.|||..|...| .|:.:|
Human   278 IHTGEKPYKCDKCGRAFISSSILYVHKISHTEEKPYKCEECGKAFKLSSILSTHKRIHTGEKPYK 342

  Fly   250 CTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFA 314
            |.:|.|.|.::..|:.|.|:|.||.|:||..|.:.|..:|.|..|.:.|:.|:|.||.:|...|.
Human   343 CEECGKAFRRSLVLRTHKRIHTGEKPYKCDKCGKAFISSSLLYKHKISHSEKKPYKCEECGKAFK 407

  Fly   315 MRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHM 379
            ..|...:|...||.|:.|||.||.|.|.:.|.|..|:.:|:||:|:||..|.|.||..::|..|.
Human   408 RSSTLTIHKISHTEEKPYKCQECDKVFKRSSALSTHKIIHSGEKPYKCEECGKAFKRSSNLTTHK 472

  Fly   380 LDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPF 444
            :.|..||:.||..|.|.||.||.|..|...|:|:|.::|..|.|::..||.|..|...|||..|:
Human   473 ISHTEEKLYKCQECDKAFKYSSALSTHKIIHSGENPYKCEECGKAFKRSSVLSKHKIIHTGAKPY 537

  Fly   445 KCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            ||..|.|.|.||::...|..:|||||||||..|...:...|.|..|.|
Human   538 KCEECGKAFKRSSQLTSHKISHTGEKPYKCEECGKAFNLSSDLNTHKR 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	165/410 (40%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF90	NP_009069.1	KRAB	4..62	CDD:214630
		C2H2 Zn finger	175..195	CDD:275368	6/19 (32%)
		COG5048	202..588	CDD:227381	157/385 (41%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		C2H2 Zn finger	315..335	CDD:275368	10/19 (53%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)