DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF70

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_068735.1	Gene:	ZNF70 / 7621	HGNCID:	13140	Length:	446	Species:	Homo sapiens

Alignment Length:	383	Identity:	139/383 - (36%)
Similarity:	202/383 - (52%)	Gaps:	31/383 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KTFTRKENLESHLRLHAEE-RPFECSHCSKSFGRRTHYKRHLLKHEKRPHKCSHCSKTFTQNSSL 152
            :||.:|.:|.....:|:|| .|.:|:...:  |.......|......:|:.|..|.|.|:|:|.|
Human    93 QTFLQKSDLSMCQIIHSEEPSPCDCAETDR--GDSGPNAPHRTPQPAKPYACRECGKAFSQSSHL 155

  Fly   153 KQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQE 217
            .:||..||||:|::|.:|..:|::.|||..|...|:.|:|:||..|.|||:.:|.|.:|.:.|..
Human   156 LRHLVIHTGEKPYECCECGKAFSQSSHLLRHQIIHTGEKPYECRECGKAFRQSSALTQHQKIHTG 220

  Fly   218 ARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCS 282
            .||::|..|.|.|...|.|:|                           |.|:|.||.|::|..|.
Human   221 KRPYECRECGKDFSRSSSLRK---------------------------HERIHTGERPYQCKECG 258

  Fly   283 ETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHL 347
            ::|.::|.|..|...|..|:|.:|..|...|..||....|.|:||.::.|||.||.|:|.:.|:|
Human   259 KSFNQSSGLSQHRKIHTLKKPHECDLCGKAFCHRSHLIRHQRIHTGKKPYKCDECGKAFSQSSNL 323

  Fly   348 VEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTG 412
            :||::.||||:|:||..|.|.|...:.|..|...|.|||..:|..|.|.|..||.|:.|.:.|||
Human   324 IEHRKTHTGEKPYKCQKCGKAFSQSSSLIEHQRIHTGEKPYECCQCGKAFCHSSALIQHQRIHTG 388

  Fly   413 KNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEK 470
            |..:.| .|.|::...|.|..|.:|||.|.|:.|:.|.|.|..|:....|.:.|:|||
Human   389 KKPYTC-ECGKAFRHRSALIEHYKTHTREKPYVCNLCGKSFRGSSHLIRHQKIHSGEK 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	139/383 (36%)
		C2H2 Zn finger	84..104	CDD:275368	4/14 (29%)
		C2H2 Zn finger	112..132	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	2/19 (11%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368
ZNF70	NP_068735.1	C2H2 Zn finger	92..108	CDD:275368	4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..138		4/25 (16%)
		COG5048	138..442	CDD:227381	124/331 (37%)
		C2H2 Zn finger	142..162	CDD:275368	9/19 (47%)
		C2H2 Zn finger	170..190	CDD:275368	7/19 (37%)
		C2H2 Zn finger	198..218	CDD:275368	8/19 (42%)
		C2H2 Zn finger	226..246	CDD:275368	9/46 (20%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..330	CDD:275368	9/19 (47%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000