DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF69

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	488	Identity:	164/488 - (33%)
Similarity:	245/488 - (50%)	Gaps:	48/488 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLANVDQRPVKDEPPQEDTFEEELIFISNSDFE-ELESEI--KIENFCSYGKDLEPVKGVPSKLK 63
            |..|..::....|....|:|....:.:.||.|. .:..:|  |...:..||.            |
Human   113 DRLNFQEKKASPEIKSCDSFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGP------------K 165

  Fly    64 TCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRH 128
            .|                 ||.|.:|.|....:..:..|.|..|:|:.|..|.|:|...:..:||
Human   166 PC-----------------KCQQPKKAFRYHPSFRTPQRDHTGEKPYACKECGKTFISHSSIQRH 213

  Fly   129 LLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERP 192
            ::.|. ..|:||..|.|.|...|....|...||||:|::|.||..||:..:.|::|.|||:.|:|
Human   214 VVMHSGDGPYKCKFCGKAFHCLSLYLIHERIHTGEKPYECKQCGKSFSYSATLRIHERTHTGEKP 278

  Fly   193 FECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKT 256
            :||..|.|||.:....:.|.|.|...:.::|..|.|:|.....::.|..||: ::.::||||.|.
Human   279 YECQQCGKAFHSPRCYRRHERIHTGEKAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQCGKA 343

  Fly   257 FLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRV 321
            .....|.|.|:|:|:||.|::|..|.:.|...:..|.|...|:|::|.||.||...|...|..|.
Human   344 LSSLTSFQTHIRMHSGERPYECKICGKGFCSANSFQRHEKTHSGEKPYKCKQCGKAFIHSSSLRY 408

  Fly   322 HVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF----------KCRTHLR 376
            |.|:||.|:.|:|.:|.|:|...|||..|.:.||||:|::|..|.|.|          :.:||:|
Human   409 HERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTHVR 473

  Fly   377 VHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGE 441
            :|.    ||:..||..|.|.|.....|..|.:.|||:..:||..|.:::::||:...|.||||||
Human   474 IHS----GERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQCGEAFSSSSSFRYHERTHTGE 534

  Fly   442 LPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKC 474
            .|:||..|.|.|..::..:.|.|||..:|||:|
Human   535 KPYKCKQCGKAFRAASVLRMHGRTHPEDKPYEC 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/413 (36%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	8/29 (28%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	1/1 (100%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..189	CDD:275368	5/19 (26%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		COG5048	222..>540	CDD:227381	122/321 (38%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		zf-H2C2_2	241..262	CDD:290200	11/20 (55%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	266..290	CDD:290200	13/23 (57%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..318	CDD:290200	7/22 (32%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	349..372	CDD:290200	10/22 (45%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		zf-H2C2_2	377..400	CDD:290200	9/22 (41%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..430	CDD:290200	11/24 (46%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		C2H2 Zn finger	449..468	CDD:275368	4/18 (22%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		zf-H2C2_2	495..520	CDD:290200	8/24 (33%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		zf-H2C2_2	523..546	CDD:290200	12/22 (55%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900