DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF66

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001342126.2	Gene:	ZNF66 / 7617	HGNCID:	13135	Length:	573	Species:	Homo sapiens

Alignment Length:	401	Identity:	161/401 - (40%)
Similarity:	216/401 - (53%)	Gaps:	12/401 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKH--EKRPHKCSHCSKT 145
            |.|:|.|.|.|.....:|.::|..|:|::|..|.|:|.|.:|...|.:.|  ||| :||..|.|.
Human   174 KFTECGKAFNRSSTFTTHKKIHTGEKPYKCIECGKAFNRSSHLTTHKIIHTGEKR-YKCEDCGKA 237

  Fly   146 FTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQE 210
            |.::|:|..|...||||:|:||.:|..:|.|.|.|..|.|.|:.|:|::|..|.|.||..|.|..
Human   238 FNRSSNLTTHKKIHTGEKPYKCEECGKAFKRSSILTTHKRIHTGEKPYKCEECGKVFKYLSSLST 302

  Fly   211 HLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-----AERSFKCTQCPKTFLQNDSLQIHLRVH 270
            |...|...:|:||..|.|:|...|    ||.||     .|:.:||.:|.|.|..:.:|..|..:|
Human   303 HKIIHTGEKPYKCEECGKAFNWSS----HLTTHKRIHTGEKPYKCEECGKGFKYSSTLTKHKIIH 363

  Fly   271 AGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCA 335
            .||.|:||..|.|.|..:..|..|.:.|.||:|.||.:|...|...|....|.|:||.|:.|||.
Human   364 TGEKPYKCEECGEAFKYSCSLTAHKIIHTGKKPYKCEECGKVFKHSSPLSKHKRIHTGEKPYKCE 428

  Fly   336 ECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLS 400
            ||.|:|.:.|.|..|:.:||||:|::|..|.|.|...::|..|...|.|||..||..|.|.||.|
Human   429 ECGKAFSRSSILTTHKIIHTGEKPYECEDCGKAFNRSSNLTKHKKIHTGEKPYKCEECGKAFKCS 493

  Fly   401 SQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRT 465
            |.|..|.:.||....::|..|.|.:..||||..|.:.|||..|.||:.|.|.|..|:....|...
Human   494 SILTTHKRIHTADKPYKCEECGKDFKYSSTLTRHKKIHTGGKPHKCNKCGKAFISSSNLSRHEII 558

  Fly   466 HTGEKPYKCSH 476
            |.|..||||.:
Human   559 HMGGNPYKCEN 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	161/401 (40%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	1/3 (33%)
ZNF66	NP_001342126.2	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	176..195	CDD:275368	6/18 (33%)
		COG5048	199..569	CDD:227381	152/374 (41%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		C2H2 Zn finger	287..307	CDD:275368	8/19 (42%)
		C2H2 Zn finger	315..335	CDD:275368	9/23 (39%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900