Protein Alignment CG5245 and ZNF43

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001243582.1
• Gene: ZNF43 / 7594
• HGNCID: 13109
• Length: 818
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 171/438 - (39%)
• Similarity: 244/438 - (55%)
• Gaps: 11/438 - (2%)

  Fly    64 TCK---------SKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSF 119
            ||:         |.:...:.:......:|||:|.:.|:|..||..|.::|.|::|::|..|.|:|
Human   352 TCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAF 416

  Fly   120 GRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVH 183
            ...:....|.|.|. ::|:||..|.|.|...|:|.:|...||||:|:||..|..:|.:.|:|..|
Human   417 KWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTH 481

  Fly   184 LRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERS 247
            .|.|:.|:|::|..|.|||..:|:|.:|.:.|.|.:|:||..|.|:||..|.|.:|.:|| .|:.
Human   482 KRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKP 546

  Fly   248 FKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSAT 312
            :||.:|.|.|.....|..|.|:|.||.|:||..|.:.|.::|.|..|...|.|::..||.:|...
Human   547 YKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKA 611

  Fly   313 FAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRV 377
            |...|....|.::||..:.|||.||.|:|.:.|.|.:|:.:||.|:|:||..|.|.||..:.|..
Human   612 FTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTK 676

  Fly   378 HMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGEL 442
            |.:.|.|||..||..|.|.|||||.|..|...|||:..::|..|.|::..||.|..|.:.||||.
Human   677 HKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQ 741

  Fly   443 PFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |:||..|.|.|..|:....|.|.||.|:||||..|...:.|.|:|..|
Human   742 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTH 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	163/405 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	10/19 (53%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	158/410 (39%)
		C2H2 Zn finger	297..317	CDD:275368
		C2H2 Zn finger	325..345	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368	2/19 (11%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	521..541	CDD:275368	8/19 (42%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)
		C2H2 Zn finger	605..625	CDD:275368	5/19 (26%)
		C2H2 Zn finger	633..653	CDD:275368	8/19 (42%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)
		C2H2 Zn finger	689..709	CDD:275368	10/19 (53%)
		C2H2 Zn finger	717..737	CDD:275368	7/19 (37%)
		COG5048	742..>803	CDD:227381	21/48 (44%)
		C2H2 Zn finger	745..765	CDD:275368	7/19 (37%)
		C2H2 Zn finger	773..793	CDD:275368	6/17 (35%)