DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and MZF1

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_005259261.1	Gene:	MZF1 / 7593	HGNCID:	13108	Length:	775	Species:	Homo sapiens

Alignment Length:	376	Identity:	149/376 - (39%)
Similarity:	201/376 - (53%)	Gaps:	18/376 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCE 199
            |..:|..|.|.|:|.|:|.:|...|||||||.|::|..||:|.|||..|..||:|||||.|..|.
Human   395 RGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCG 459

  Fly   200 KAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAE------------------R 246
            :.|..::.|:||.|.|...:||:|:.|.:||:.||.|.:|...|.:                  .
Human   460 QGFVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPG 524

  Fly   247 SFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSA 311
            .|.|::|.::|.:...|..|..||.|:..|.|..|.|.|.|.|.|..|...|:|:.|..|::|..
Human   525 PFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQ 589

  Fly   312 TFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLR 376
            :|..||....|.|:||.||.:.||||.|:|.::..|.:|.:|||||:||.|..|.:.|..|..|.
Human   590 SFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLT 654

  Fly   377 VHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGE 441
            .|...|.|||...|..|...|...|:|..|.:.|||:..|.||.|.:|:...:.|..|.|.||||
Human   655 RHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGE 719

  Fly   442 LPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            .|:.|..|.|.|.:.....:|||||..|||:.|..|..|:.|.:.|.:|.|
Human   720 RPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQR 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	143/360 (40%)
		C2H2 Zn finger	84..104	CDD:275368
		C2H2 Zn finger	112..132	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	13/24 (54%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
MZF1	XP_005259261.1	SCAN	81..193	CDD:128708
		COG5048	399..757	CDD:227381	143/357 (40%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275370	8/19 (42%)
		C2H2 Zn finger	528..548	CDD:275368	5/19 (26%)
		C2H2 Zn finger	556..576	CDD:275368	8/19 (42%)
		C2H2 Zn finger	584..604	CDD:275368	7/19 (37%)
		C2H2 Zn finger	612..632	CDD:275368	8/19 (42%)
		C2H2 Zn finger	640..660	CDD:275368	6/19 (32%)
		C2H2 Zn finger	668..688	CDD:275368	6/19 (32%)
		C2H2 Zn finger	696..716	CDD:275368	7/19 (37%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
		C2H2 Zn finger	752..772	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910