DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF35

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003411.3	Gene:	ZNF35 / 7584	HGNCID:	13099	Length:	527	Species:	Homo sapiens

Alignment Length:	395	Identity:	135/395 - (34%)
Similarity:	217/395 - (54%)	Gaps:	29/395 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PSKLKTC-KSKIAKKRPLRKQTDTFK---CTQCQ--KTFTRKENLESHLRLHAEERPFECSHCSK 117
            |...:.| |..:.|::.::::...|:   ...|.  ::|..:||                ..|.|
Human   150 PELGEACEKGNMLKRQRIKREKKDFRQVIVNDCHLPESFKEEEN----------------QKCKK 198

  Fly   118 SFGRRTHYKRHLLKHEK-----RPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARK 177
            |.|:.: .....:|:.|     :|..||.|.|.|:|:::|..|...||||:||:|.:|..:|.:.
Human   199 SGGKYS-LNSGAVKNPKTQLGQKPFTCSVCGKGFSQSANLVVHQRIHTGEKPFECHECGKAFIQS 262

  Fly   178 SHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLT 242
            ::|.||.|.|:.::|:.|:.|.|||..:|:|..|.:.|...:.|||:.|.|:|...|.|.:|...
Human   263 ANLVVHQRIHTGQKPYVCSKCGKAFTQSSNLTVHQKIHSLEKTFKCNECEKAFSYSSQLARHQKV 327

  Fly   243 H-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKC 306
            | .|:.::|.:|.|||.::.:|.:|.|:|.||.||.|..|.:.|.:::.|.:|...|.|::|.:|
Human   328 HITEKCYECNECGKTFTRSSNLIVHQRIHTGEKPFACNDCGKAFTQSANLIVHQRSHTGEKPYEC 392

  Fly   307 SQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKC 371
            .:|...|:..|...||.|:||.|:.|.|:||.|:|.:.|.|:.||::|:|:.|:.|..|.|.|.|
Human   393 KECGKAFSCFSHLIVHQRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLPYVCNECGKAFTC 457

  Fly   372 RTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLR 436
            .::|.:|...|.|||...|:.|.|.|:..|.|.||.:.|||:..:||..|..::.::|.|..|.|
Human   458 SSYLLIHQRIHNGEKPYTCNECGKAFRQRSSLTVHQRTHTGEKPYECEKCGAAFISNSHLMRHHR 522

  Fly   437 THTGE 441
            ||..|
Human   523 THLVE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	131/379 (35%)
		C2H2 Zn finger	84..104	CDD:275368	4/21 (19%)
		C2H2 Zn finger	112..132	CDD:275368	4/19 (21%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..492	CDD:275368
ZNF35	NP_003411.3	Globular domain	9..221		15/87 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..38
		COG5048	<214..369	CDD:227381	60/154 (39%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	8/19 (42%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		COG5048	372..>449	CDD:227381	28/76 (37%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		zf-H2C2_2	460..485	CDD:316026	10/24 (42%)
		zf-C2H2	474..496	CDD:306579	8/21 (38%)
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		zf-H2C2_2	488..513	CDD:316026	9/24 (38%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810