DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF28

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_008900.3	Gene:	ZNF28 / 7576	HGNCID:	13073	Length:	718	Species:	Homo sapiens

Alignment Length:	471	Identity:	181/471 - (38%)
Similarity:	266/471 - (56%)	Gaps:	41/471 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KTCKSKI-----AKKRPL----RKQTD--TFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCS 116
            |.||..:     .:||.|    |...|  .:||.:|.|.|....:|..|..||..::|:||..|.
Human   241 KQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKCNECGKIFGHNTSLFLHKALHTADKPYECEECD 305

  Fly   117 KSFGRRTHYKRH------------------------LLKHE-----KRPHKCSHCSKTFTQNSSL 152
            |.|.|::|.:.|                        |.||.     ::|:||:.|.|.|.:.|:|
Human   306 KVFSRKSHLETHKIIYTGGKPYKCKVCDKAFTCNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTL 370

  Fly   153 KQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQE 217
            .:|...||||:|::|.:|...|:|||||:.|.|.|:.|:|::|..|:|||..||:|.:|...|..
Human   371 ARHRRLHTGEKPYECEECEKVFSRKSHLERHKRIHTGEKPYKCKVCDKAFAYNSYLAKHSIIHTG 435

  Fly   218 ARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHC 281
            .:|:||:.|.|.|..:|.|.:|...| ||:.:||.:|.|.|.....|:.|.|:|.||.|:||..|
Human   436 EKPYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEECDKVFRCKSHLERHRRIHTGEKPYKCKVC 500

  Fly   282 SETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSH 346
            .:.|..:|.|..|...|.|::|..|::|...|:.::....|.:|||.|:.|||.||.|.|.:|||
Human   501 DKAFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKANLACHHKLHTAEKPYKCEECEKVFSRKSH 565

  Fly   347 LVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHT 411
            :..|:::||||:|:||..|.|.|:..:||..|...|.|||..||:.|.|.|:.:|.|::|.:.||
Human   566 MERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHQRVHTGEKPYKCNECGKTFRQTSSLIIHRRLHT 630

  Fly   412 GKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSH 476
            |:..::|..|.|:::..|:|..|.|.|:||.|:||:.|.|:|.:.|...:|.|.|||||||||:.
Human   631 GEKPYKCNECGKTFSQMSSLVYHHRLHSGEKPYKCNECGKVFNQQAHLAQHQRVHTGEKPYKCNE 695

  Fly   477 CSTRYTQKSSLGRHLR 492
            |...::|.|:|..|.|
Human   696 CGKTFSQMSNLVYHHR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	170/439 (39%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	8/43 (19%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	4/19 (21%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
ZNF28	NP_008900.3	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<143..373	CDD:227381	37/131 (28%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368	4/19 (21%)
		COG5048	267..655	CDD:227381	146/387 (38%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	329..349	CDD:275368	3/19 (16%)
		zf-H2C2_2	341..366	CDD:290200	9/24 (38%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	10/23 (43%)
		C2H2 Zn finger	385..405	CDD:275368	10/19 (53%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	425..450	CDD:290200	9/24 (38%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	481..506	CDD:290200	11/24 (46%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	8/23 (35%)
		C2H2 Zn finger	525..545	CDD:275368	4/19 (21%)
		C2H2 Zn finger	553..573	CDD:275368	9/19 (47%)
		zf-H2C2_2	565..590	CDD:290200	12/24 (50%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
		zf-H2C2_2	593..618	CDD:290200	12/24 (50%)
		C2H2 Zn finger	609..629	CDD:275368	7/19 (37%)
		zf-H2C2_2	621..646	CDD:290200	8/24 (33%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		C2H2 Zn finger	665..685	CDD:275368	7/19 (37%)
		zf-H2C2_2	677..702	CDD:290200	12/24 (50%)
		C2H2 Zn finger	693..713	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810