DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF23

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001368913.1	Gene:	ZNF23 / 7571	HGNCID:	13023	Length:	686	Species:	Homo sapiens

Alignment Length:	470	Identity:	169/470 - (35%)
Similarity:	261/470 - (55%)	Gaps:	22/470 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TFEEELI--FISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTF 82
            :|:.:|:  .|.||:....:.|..:|.|                  .|.|::.:.:....:...:
Human   193 SFDTKLVKHEIINSEERPFKCEELVEPF------------------RCDSQLIQHQENNTEEKPY 239

  Fly    83 KCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTF 146
            :|::|.|.|:..|.|..|.|||:.|:||:|..|.|||...:||..|...|. ::|::|..|.|.|
Human   240 QCSECGKAFSINEKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKMCGKAF 304

  Fly   147 TQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEH 211
            :.|.||.:|...||||:|::|.:|...|:..|....|.|.|:.|:|:||..|.|||..|:.|.:|
Human   305 SVNGSLSRHQRIHTGEKPYQCKECGNGFSCSSAYITHQRVHTGEKPYECNDCGKAFNVNAKLIQH 369

  Fly   212 LRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDP 275
            .|.|...:|::|:.|.|.|:..|.|::|...| .|:.::|.:|.|.|..|..|..|.|:|.||.|
Human   370 QRIHTGEKPYECNECGKGFRCSSQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGEKP 434

  Fly   276 FKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKS 340
            ::|..|.:.|:...:|..|...|.|::|.:|::|...|...|.:|.|:|:||.|:.|:|.||.|:
Human   435 YECTECGKAFSVKGKLIQHQRIHTGEKPYECNECGKAFRCNSQFRQHLRIHTGEKPYECNECGKA 499

  Fly   341 FFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLV 405
            |.....|:.||::||||:||:|..|.:.|..:.:|..|...|.|||..:|..|.|.|.::::|..
Human   500 FSVNGKLMRHQRIHTGEKPFECNECGRCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTR 564

  Fly   406 HLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEK 470
            |.:.|||:..|:|..|.|:::.||...:|.|.||||.||:|..|.|.|..:|....|.|:|||||
Human   565 HQRIHTGEKPFKCMECEKAFSCSSNYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEK 629

  Fly   471 PYKCSHCSTRYTQKS 485
            |::|..|...::..|
Human   630 PFRCVECGKGFSFSS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	157/405 (39%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	3/12 (25%)
ZNF23	NP_001368913.1	KRAB	14..73	CDD:214630
		C2H2 Zn finger	185..205	CDD:275368	3/11 (27%)
		C2H2 Zn finger	213..233	CDD:275368	5/37 (14%)
		COG5048	229..649	CDD:227381	159/416 (38%)
		C2H2 Zn finger	241..261	CDD:275368	8/19 (42%)
		C2H2 Zn finger	269..289	CDD:275368	8/19 (42%)
		C2H2 Zn finger	297..317	CDD:275368	8/19 (42%)
		C2H2 Zn finger	325..345	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	8/19 (42%)
		C2H2 Zn finger	521..541	CDD:275368	5/19 (26%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	7/19 (37%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		C2H2 Zn finger	633..653	CDD:275368	3/12 (25%)
		C2H2 Zn finger	661..681	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900