DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF182

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001171570.1	Gene:	ZNF182 / 7569	HGNCID:	13001	Length:	639	Species:	Homo sapiens

Alignment Length:	496	Identity:	193/496 - (38%)
Similarity:	279/496 - (56%)	Gaps:	28/496 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QRPVKDEPPQEDTFEEELIFISNSD-FEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAK 71
            |||.|.|     :|...:  :.|.| |....:|.|.:|.|             :|| ...::..|
Human   155 QRPDKHE-----SFGNNM--VDNLDLFSRSSAENKYDNGC-------------AKL-FFHTEYEK 198

  Fly    72 KRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KR 135
            ..|..|   .:...:|.|...||:.|..|.|:...|:||||:.|.|:|.:::|...|...|. ::
Human   199 TNPGMK---PYGYKECGKGLRRKKGLSLHQRIKNGEKPFECTACRKTFSKKSHLIVHWRTHTGEK 260

  Fly   136 PHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEK 200
            |..|:.|.|.|:|.|.|..||..|||||||:|.:|..:|..||.:.:|.|||:.|:|:||..|.|
Human   261 PFGCTECGKAFSQKSQLIIHLRTHTGERPFECPECGKAFREKSTVIIHYRTHTGEKPYECNECGK 325

  Fly   201 AFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQ 264
            ||...|:|..|.:||...:.::|:.|.:||..:..|..|..|| .::..:|.:|.|||....:|.
Human   326 AFTQKSNLIVHQKTHTGEKTYECTKCGESFIQKLDLIIHHSTHTGKKPHECNECKKTFSDKSTLI 390

  Fly   265 IHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRE 329
            ||.|.|.||.|.||..|.::|...|.|.:|...|.|::|.:|..|..||..:|...||.|.|:.|
Human   391 IHQRTHTGEKPHKCTECGKSFNEKSTLIVHQRTHTGEKPYECDVCGKTFTQKSNLGVHQRTHSGE 455

  Fly   330 RQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCS 394
            :.::|.||.|:|.:||:|:.||:.||||:|::|..|.|.|..:::|.:|...|..||..||:.|.
Human   456 KPFECNECEKAFSQKSYLMLHQRGHTGEKPYECNECEKAFSQKSYLIIHQRTHTEEKPYKCNECG 520

  Fly   395 KEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEH 459
            |.|:..|:|::|.:.|||:..:|||.|.|:::..|.|.:|.||||||.|:.|:.|.|.|...:..
Human   521 KAFREKSKLIIHQRIHTGEKPYECPVCWKAFSQKSQLIIHQRTHTGEKPYACTECGKAFREKSTF 585

  Fly   460 QEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTKS 500
            ..|.|||||||||||:.|...:||||:|..| :||..|.|:
Human   586 TVHQRTHTGEKPYKCTECGKAFTQKSNLIVH-QRTHAGKKA 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	166/405 (41%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	8/17 (47%)
ZNF182	NP_001171570.1	KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		COG5048	147..553	CDD:227381	156/421 (37%)
		C2H2 Zn finger	209..228	CDD:275368	7/18 (39%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		zf-H2C2_2	277..299	CDD:290200	12/21 (57%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..329	CDD:290200	12/20 (60%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	332..357	CDD:290200	8/24 (33%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		zf-C2H2	374..396	CDD:278523	9/21 (43%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..412	CDD:290200	11/22 (50%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		zf-H2C2_2	417..441	CDD:290200	9/23 (39%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		zf-H2C2_2	444..469	CDD:290200	10/24 (42%)
		C2H2 Zn finger	460..480	CDD:275368	10/19 (53%)
		zf-H2C2_2	472..497	CDD:290200	12/24 (50%)
		C2H2 Zn finger	488..508	CDD:275368	6/19 (32%)
		zf-H2C2_2	500..523	CDD:290200	9/22 (41%)
		C2H2 Zn finger	516..536	CDD:275368	7/19 (37%)
		zf-H2C2_2	529..553	CDD:290200	10/23 (43%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		zf-H2C2_2	557..579	CDD:290200	12/21 (57%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	587..609	CDD:290200	13/21 (62%)
		C2H2 Zn finger	600..620	CDD:275368	9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..639		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810