DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF20

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_066966.2	Gene:	ZNF20 / 7568	HGNCID:	12992	Length:	532	Species:	Homo sapiens

Alignment Length:	475	Identity:	159/475 - (33%)
Similarity:	236/475 - (49%)	Gaps:	39/475 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLE 98
            |..||....|:|.....|:...|.:|. :..|:|.:                 |.:..|...:|.
Human    75 ESKESHHCGESFNQIADDMLNRKTLPG-ITPCESSV-----------------CGEVGTGHSSLN 121

  Fly    99 SHLRL---HAE-------ERPFECSHCSKSFGRRTHYKRHLLKHEK-----RPHKCSHCSKTFTQ 148
            :|:|.   |..       |.|:....|.|:|.    |......|:|     :|:....|::||..
Human   122 THIRADTGHKSSEYQEYGENPYRNKECKKAFS----YLDSFQSHDKACTKEKPYDGKECTETFIS 182

  Fly   149 NSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLR 213
            :|.:::|...|:|:.|:||..|..:|...:...:|.|.|:..:|::|..|.|||..::.|..|.|
Human   183 HSCIQRHRVMHSGDGPYKCKFCGKAFYFLNLCLIHERIHTGVKPYKCKQCGKAFTRSTTLPVHER 247

  Fly   214 THQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFK 277
            ||......:|..|..:|...|.:::|..:| .|:.::|.||.|.|:...|:|.|...|.||.|::
Human   248 THTGVNADECKECGNAFSFPSEIRRHKRSHTGEKPYECKQCGKVFISFSSIQYHKMTHTGEKPYE 312

  Fly   278 CPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFF 342
            |..|.:.|...|.||.|...|.|::|.:|.||...|...|..:.|.:.||.::.|.|.:|.|.|.
Human   313 CKQCGKAFRCGSHLQKHGRTHTGEKPYECRQCGKAFRCTSDLQRHEKTHTEDKPYGCKQCGKGFR 377

  Fly   343 KKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHL 407
            ..|.|..|::.|:||:|.:|..|.|.||..:.||:|...|.|||..:|..|.|.|:..|.|.:|.
Human   378 CASQLQIHERTHSGEKPHECKECGKVFKYFSSLRIHERTHTGEKPHECKQCGKAFRYFSSLHIHE 442

  Fly   408 QEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPY 472
            :.|||...:||..|.|::|.||::..|.||||||.|::|.||.|.|. |...:.|.|||||||||
Human   443 RTHTGDKPYECKVCGKAFTCSSSIRYHERTHTGEKPYECKHCGKAFI-SNYIRYHERTHTGEKPY 506

  Fly   473 KCSHCSTRYTQKSSLGRHLR 492
            :|..|...:.:.||...|.|
Human   507 QCKQCGKAFIRASSCREHER 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	144/419 (34%)
		C2H2 Zn finger	84..104	CDD:275368	5/22 (23%)
		C2H2 Zn finger	112..132	CDD:275368	4/19 (21%)
		C2H2 Zn finger	139..159	CDD:275368	5/19 (26%)
		C2H2 Zn finger	167..187	CDD:275368	5/19 (26%)
		zf-H2C2_2	179..204	CDD:290200	9/24 (38%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF20	NP_066966.2	KRAB	7..>47	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	108..127	CDD:275368	5/35 (14%)
		COG5048	115..525	CDD:227381	146/414 (35%)
		C2H2 Zn finger	146..165	CDD:275368	6/22 (27%)
		C2H2 Zn finger	173..193	CDD:275368	5/19 (26%)
		C2H2 Zn finger	201..221	CDD:275370	5/19 (26%)
		zf-H2C2_2	217..238	CDD:290200	9/20 (45%)
		C2H2 Zn finger	229..249	CDD:275368	8/19 (42%)
		C2H2 Zn finger	257..277	CDD:275368	5/19 (26%)
		zf-H2C2_2	271..294	CDD:290200	8/22 (36%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		zf-H2C2_2	297..322	CDD:290200	10/24 (42%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		C2H2 Zn finger	341..361	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		zf-H2C2_2	382..406	CDD:290200	10/23 (43%)
		C2H2 Zn finger	397..417	CDD:275368	8/19 (42%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	441..462	CDD:290200	8/20 (40%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	13/25 (52%)
		C2H2 Zn finger	481..500	CDD:275368	8/19 (42%)
		zf-H2C2_2	494..517	CDD:290200	12/22 (55%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900