DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF14

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_066358.2	Gene:	ZNF14 / 7561	HGNCID:	12924	Length:	642	Species:	Homo sapiens

Alignment Length:	521	Identity:	174/521 - (33%)
Similarity:	269/521 - (51%)	Gaps:	44/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLANVDQRPVKDEPPQEDTF-EEELIFISN-------------SDFEELESEIKIENFCSYGKD 51
            |...|:::.......|.|.:| ..:.|..|:             ::::|.|.:
Human    87 MPNVNINKETFTGAKPHECSFCGRDFIHHSSLNRHMRSHTGQKPNEYQEYEKQ------------ 139

  Fly    52 LEPVKGVPSKLKTCKSKIAKKRPLRKQTDT------FKCTQCQKTFTRKENLESHLRLHAEERPF 110
                   |.|.|......:.....||...|      ::|.||.|.|...:..:.|.|.||.::|:
Human   140 -------PCKCKAVGKTFSYHHCFRKHERTHTGVKPYECKQCGKAFIYYQPFQRHERTHAGQKPY 197

  Fly   111 ECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSF 174
            ||..|.|:|.....:::|  .|. |:|::|..|.|.|....|.::|...||||:|::|.||..:|
Human   198 ECKQCGKTFIYYQSFQKH--AHTGKKPYECKQCGKAFICYQSFQRHKRTHTGEKPYECKQCGKAF 260

  Fly   175 ARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKH 239
            :..::.:.|.|||:.|:|::|..|.|||...|..:.|.|||...:|::|..|.|:|...:..:.|
Human   261 SCPTYFRTHERTHTGEKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAH 325

  Fly   240 LLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEP 303
            ::.| ..|.:||.:|.|.|..::|.::|.|.|.||.|::|..|.::|:.:..|:||...|.|::|
Human   326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSISLRLHERTHTGEKP 390

  Fly   304 LKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKD 368
            .:|.||..||:..|..|.|...||.|:.|:|.:|.|:|...|.|..|::.|..|:|::|..|.|.
Human   391 YECKQCHKTFSFSSSLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKA 455

  Fly   369 FKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHM 433
            |:|.::.|:|...|.|||..:|..|.|.|..||...:|.:.|||:..:||..|.|:::.||:|..
Human   456 FRCSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERTHTGEKPYECKLCGKTFSFSSSLRE 520

  Fly   434 HLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGT 498
            |.:.|||..||:|..|.|.|.||::.:.|.|||||||||:|..|...:...|....| .||..|.
Human   521 HEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCGKAFISSSKFRMH-ERTHTGE 584

  Fly   499 K 499
            |
Human   585 K 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	155/411 (38%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	4/17 (24%)
ZNF14	NP_066358.2	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	80..97	CDD:275368	2/9 (22%)
		C2H2 Zn finger	105..125	CDD:275368	3/19 (16%)
		C2H2 Zn finger	143..163	CDD:275368	3/19 (16%)
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
		C2H2 Zn finger	199..217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		zf-H2C2_2	237..262	CDD:290200	11/24 (46%)
		COG5048	249..633	CDD:227381	130/338 (38%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	265..289	CDD:290200	10/23 (43%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		zf-H2C2_2	293..316	CDD:290200	8/22 (36%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		zf-H2C2_2	377..401	CDD:290200	10/23 (43%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..429	CDD:290200	9/23 (39%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		zf-H2C2_2	461..486	CDD:290200	10/24 (42%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		zf-H2C2_2	517..542	CDD:290200	11/24 (46%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		C2H2 Zn finger	561..581	CDD:275368	5/20 (25%)
		zf-H2C2_2	574..596	CDD:290200	5/13 (38%)
		C2H2 Zn finger	589..609	CDD:275368
		zf-H2C2_2	601..626	CDD:290200
		C2H2 Zn finger	617..637	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900