DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp263

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_683726.2	Gene:	Zfp263 / 74120	MGIID:	1921370	Length:	680	Species:	Mus musculus

Alignment Length:	473	Identity:	148/473 - (31%)
Similarity:	197/473 - (41%)	Gaps:	141/473 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDQRPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKI- 69
            :|.|....|.|.||..||.|:                              |.||    ||..:
Mouse   339 LDDREGHWECPPEDKIEESLV------------------------------GTPS----CKGLVQ 369

  Fly    70 AKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHY-KRHLLKHE 133
            ||::|.:...    |..|.|.|:...||..|.|:||.|:......|.:.||...|: ..|.....
Mouse   370 AKEQPKKLHL----CALCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHIG 430

  Fly   134 KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHC 198
            :..|||..|.|.|:||:.|.:|...||||:||:|..|..||:..|:|..|.|||:.|:|::|..|
Mouse   431 EEAHKCLECGKCFSQNTHLTRHQRTHTGEKPFQCNACGKSFSCNSNLNRHQRTHTGEKPYKCPEC 495

  Fly   199 EKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHAERSFKCTQCPKTFLQNDSL 263
            .:.|.::|:|..|.|.|...||::||.|.|||...|    ||:
Mouse   496 GEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSS----HLV---------------------- 534

  Fly   264 QIHLRVHAGE--DPFKCPHC------SETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYR 320
             ||.|.|..|  |||  |.|      |..|..|.|::..|.|
Mouse   535 -IHERTHEKERLDPF--PECGQGMNDSAPFLTNHRVEKKLFE----------------------- 573

  Fly   321 VHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGE 385
                         |:.|.|||.:..||..||:.||||:|:||..|.::|..|
Mouse   574 -------------CSTCGKSFRQGMHLTRHQRTHTGEKPYKCILCGENFSHR------------- 612

  Fly   386 KVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCS 450
                           |.|:.|.:.|||:..:.|..|..|::.||....||||||||.|:|||.|.
Mouse   613 ---------------SNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECG 662

  Fly   451 KLFARSAEHQEHLRTHTG 468
            :.|:||:....|.|||||
Mouse   663 ESFSRSSRLTSHQRTHTG 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	132/404 (33%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	5/20 (25%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	3/19 (16%)
		C2H2 Zn finger	278..298	CDD:275368	7/25 (28%)
		C2H2 Zn finger	306..326	CDD:275368	0/19 (0%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	4/19 (21%)
		C2H2 Zn finger	390..410	CDD:275368	3/19 (16%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368
Zfp263	NP_683726.2	SCAN	41..151	CDD:128708
		SCAN	41..127	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..191
		KRAB_A-box	219..253	CDD:143639
		KRAB	220..278	CDD:214630
		C2H2 Zn finger	380..400	CDD:275368	8/19 (42%)
		zf-C2H2	380..400	CDD:278523	8/19 (42%)
		COG5048	<415..646	CDD:227381	97/323 (30%)
		zf-C2H2	434..456	CDD:278523	10/21 (48%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		zf-H2C2_2	448..473	CDD:290200	12/24 (50%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		zf-H2C2_2	476..501	CDD:290200	10/24 (42%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		zf-H2C2_2	504..529	CDD:290200	12/24 (50%)
		C2H2 Zn finger	520..540	CDD:275368	12/46 (26%)
		zf-C2H2	572..594	CDD:278523	10/57 (18%)
		C2H2 Zn finger	574..594	CDD:275368	9/19 (47%)
		zf-H2C2_2	586..611	CDD:290200	13/24 (54%)
		C2H2 Zn finger	602..622	CDD:275368	7/47 (15%)
		zf-H2C2_2	614..639	CDD:290200	8/24 (33%)
		COG5048	626..>679	CDD:227381	24/52 (46%)
		C2H2 Zn finger	630..650	CDD:275368	8/19 (42%)
		zf-H2C2_2	645..667	CDD:290200	14/21 (67%)
		C2H2 Zn finger	658..678	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000