DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp433

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_011241889.1	Gene:	Zfp433 / 73610	MGIID:	1920860	Length:	619	Species:	Mus musculus

Alignment Length:	505	Identity:	189/505 - (37%)
Similarity:	272/505 - (53%)	Gaps:	50/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRK------QTD 80
            :.:.||..| :|.::...|:.|.             .|.....|....|..|.|||      :..
Mouse   101 KNQYIFACN-NFLQIYDRIQTEE-------------KPYGCSQCSKAFANFRSLRKHEKNHTREK 151

  Fly    81 TFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSK 144
            .::|:||.|.|..:.:|:.|.|.|..|:.::|:.|.|:|..|:|.:.|...|. ::|:.||.|.|
Mouse   152 PYECSQCSKAFVSRSSLQIHERTHTREKLYDCNECGKAFSTRSHLQIHKRTHTGEKPYDCSECGK 216

  Fly   145 TFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQ 209
            .|.::|:|..|...||||:|:.|.:|..:||.:||||:|.|||:.|:|::|..|.|||....|||
Mouse   217 AFARSSALLIHKRSHTGEKPYGCNECGKAFACRSHLQIHKRTHTGEKPYDCDECGKAFATRRHLQ 281

  Fly   210 EHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGE 273
            .|.|||...:|::|:.|.|:|..||.||.|...| .|:.::|.||.|.|..|..|..|..:|.||
Mouse   282 IHERTHTGEKPYECNQCGKAFIGRSHLQIHKRVHTGEKPYECNQCGKAFAYNSDLHRHEIIHTGE 346

  Fly   274 DPFKCPHCSETFARNSRL----QLHLLE------------------------HAGKEPLKCSQCS 310
            .|:.|..|.:.||..|.|    :.|.||                        |.|::|..|:||.
Mouse   347 KPYGCNQCGKAFANRSSLRNHEEHHTLEKPYECTLCGKAFAYCSNLYIHERCHTGEKPYVCTQCG 411

  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375
            ..||.||...:|.|.||.|:.|.|.:|.|:|.::|||..|:::|.||:|::|..|.|.|..|:.|
Mouse   412 KAFARRSHLHIHERCHTGEKPYVCTQCGKAFARRSHLHVHERIHAGEKPYECNQCGKAFLLRSSL 476

  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440
            .:|...|.|||...|:.|.|.|...|.|.:|.:.|||:..:||..|||::...|.|.||.|||||
Mouse   477 LIHERTHTGEKPYVCNQCGKAFARQSHLQIHERSHTGEKPYECNQCSKAFVCRSNLQMHERTHTG 541

  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |.|::|:.|.|.|:|.:..|:|.|:|:|||||.|:.|...:..:|||..|
Mouse   542 ERPYECNQCGKAFSRRSLLQKHERSHSGEKPYACNQCGKAFASRSSLRNH 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	174/439 (40%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		zf-H2C2_2	179..204	CDD:290200	14/24 (58%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	9/47 (19%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		C2H2 Zn finger	334..354	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Zfp433	XP_011241889.1	KRAB	23..63	CDD:396083
		C2H2 Zn finger	127..147	CDD:275368	6/19 (32%)
		zf-H2C2_2	139..164	CDD:404364	8/24 (33%)
		C2H2 Zn finger	155..175	CDD:275368	8/19 (42%)
		COG5048	179..594	CDD:227381	166/413 (40%)
		C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..259	CDD:275368	10/19 (53%)
		C2H2 Zn finger	267..287	CDD:275368	10/19 (53%)
		C2H2 Zn finger	295..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..367	CDD:275368	6/15 (40%)
		C2H2 Zn finger	379..399	CDD:275368	0/19 (0%)
		C2H2 Zn finger	407..427	CDD:275368	9/19 (47%)
		C2H2 Zn finger	435..455	CDD:275368	8/19 (42%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	9/19 (47%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		C2H2 Zn finger	575..595	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900