Protein Alignment CG5245 and ZNF726

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001230967.1
• Gene: ZNF726 / 730087
• HGNCID: 32462
• Length: 616
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 192/550 - (34%)
• Similarity: 278/550 - (50%)
• Gaps: 62/550 - (11%)

  Fly     5 NVDQRPVKDEPP---------------QEDTFEEELI-FISNSDFEELE--------SEIKIE-- 43
            |:.:..:.||||               .||:|::.:: .......|.|:        .|.|:.
Human    64 NMKRDEMVDEPPGICPHFAQDIWPEQGVEDSFQKVILRRFEKCGHENLQLRKGCKSVDECKVHKE 128

  Fly    44 -----NFC---SYGK--------------------DLEPVKGVPSKLKTCK------SKIAKKRP 74
                 |.|   :.||                    .:...:..|.|.|.|.      |...:.:.
Human   129 GYNGLNQCFTTTQGKASQCGKYLKVFYKFINLNRYKIRHTRKKPFKCKNCVKSFCMFSHKTQHKS 193

  Fly    75 LRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHK 138
            :.....::||.:|.|||.....|.:|.:.|.||:|::|....|:|.:.::|..|.:.|. ::|:|
Human   194 IYTTEKSYKCKECGKTFNWSSTLTNHKKTHTEEKPYKCEEYGKAFNQSSNYTTHKVTHTGEKPYK 258

  Fly   139 CSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFK 203
            |..|.|.|:|:|:|..|...||||:|.||.:|..:|::.|.|.:|.|.|..|:|::|..|.|||.
Human   259 CEECGKAFSQSSTLTIHKRIHTGEKPCKCEECGKAFSQPSALTIHKRMHIGEKPYKCEECGKAFV 323

  Fly   204 NNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHL 267
            .:|.|..|.|.|...:|:||..|:|:|.....|..|.:.| .|:.:||.:|.|.|:...:|..|.
Human   324 WSSTLTRHKRLHSGEKPYKCEECAKAFSQFGHLTTHRIIHTGEKPYKCEECGKAFIWPSTLTKHK 388

  Fly   268 RVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQY 332
            |:|.||.|:||..|.:.|.|:|.|..|.:.|.|::|.||.:|...|...|....|.::||||:.|
Human   389 RIHTGEKPYKCEECGKAFHRSSNLTKHKIIHTGEKPYKCEECGKAFIWSSNLTEHKKIHTREKPY 453

  Fly   333 KCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEF 397
            ||.||||:|.:.|.|..|:::||||:|:||..|.|.|...:.|..|.:.|.|||..||..|.|.|
Human   454 KCEECSKAFSRSSALTTHKRMHTGEKPYKCEECGKAFSQSSTLTAHKIIHTGEKPYKCEECGKAF 518

  Fly   398 KLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEH 462
            .|||.|..|.:.|||:..::|..|.|::..||.|..|...||||.|:||..|.|.|.||:....|
Human   519 ILSSTLSKHKRIHTGEKPYKCEECGKTFNQSSNLSTHKIIHTGEKPYKCEECGKAFNRSSNLSTH 583

  Fly   463 LRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            ...|||||||||..|...:...|:|.:|.|
Human   584 KIIHTGEKPYKCDECGKSFIWSSTLFKHKR 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	166/405 (41%)
		C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF726	NP_001230967.1	KRAB	4..64	CDD:214630	191/549 (35%)
		C2H2 Zn finger	145..167	CDD:275368	0/21 (0%)
		C2H2 Zn finger	175..195	CDD:275368	3/19 (16%)
		COG5048	186..612	CDD:227381	170/425 (40%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		C2H2 Zn finger	315..335	CDD:275368	9/19 (47%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	9/19 (47%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	5/18 (28%)