DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and ZNF814

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001138461.1	Gene:	ZNF814 / 730051	HGNCID:	33258	Length:	855	Species:	Homo sapiens

Alignment Length:	421	Identity:	179/421 - (42%)
Similarity:	243/421 - (57%)	Gaps:	4/421 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RKQTDT--FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPH 137
            |..||.  ::|.:|.|:|::|.:|..|.|.|..|:|:.|..|.|||....|.:.|...|. :||.
Human   400 RVHTDKKHYECGECGKSFSQKSSLIQHQRFHTGEKPYGCEECGKSFSSEGHLRSHQRVHAGERPF 464

  Fly   138 KCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAF 202
            ||..|.|:|:...||..|...|:||||::|.:|..||::|.:|.:|.|.|:..||:||..|.|:|
Human   465 KCGECVKSFSHKRSLVHHQRVHSGERPYQCGECGKSFSQKGNLVLHQRVHTGARPYECGECGKSF 529

  Fly   203 KNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIH 266
            .:..||:.|.:.|...|.::|..|.|||..:..|..|...| .|||:.|.:|.|:|.....|:.|
Human   530 SSKGHLRNHQQIHTGDRLYECGECGKSFSHKGTLILHQRVHPRERSYGCGECGKSFSSIGHLRSH 594

  Fly   267 LRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQ 331
            .|||.||.|::|..|.::|:....|..|...|.|:.|.||..|..:|..:...|.|.|:||.||.
Human   595 QRVHTGERPYECGECGKSFSHKRSLVHHQRMHTGERPYKCGDCGKSFNEKGHLRNHQRVHTTERP 659

  Fly   332 YKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKE 396
            :||.||.|.|..|.:|:.||..||||||:.|..|.|.||.::||.||...|.|||...|..|.|.
Human   660 FKCGECGKCFSHKGNLILHQHGHTGERPYVCRECGKLFKKKSHLLVHQRIHNGEKPYACEACQKF 724

  Fly   397 FKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQE 461
            |:...||:.|.:.|||:..:||..|.||:|.|||..:|.|.||||.|::||.|.|.||.|:...:
Human   725 FRNKYQLIAHQRVHTGERPYECNDCGKSFTHSSTFCVHKRIHTGEKPYECSECGKSFAESSSFTK 789

  Fly   462 HLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492
            |.|.|||||||:||.|...:.:.|||.:|.|
Human   790 HKRVHTGEKPYECSECGKSFAESSSLTKHKR 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	173/405 (43%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	7/19 (37%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	9/19 (47%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	10/19 (53%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	7/17 (41%)
ZNF814	NP_001138461.1	KRAB	15..>56	CDD:214630
		KRAB	15..54	CDD:279668
		C2H2 Zn finger	176..192	CDD:275368
		COG5048	214..650	CDD:227381	94/249 (38%)
		C2H2 Zn finger	216..236	CDD:275368
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	271..291	CDD:275368
		C2H2 Zn finger	298..318	CDD:275368
		C2H2 Zn finger	326..346	CDD:275368
		C2H2 Zn finger	354..374	CDD:275368
		C2H2 Zn finger	382..402	CDD:275368	1/1 (100%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		COG5048	462..850	CDD:227381	157/359 (44%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..514	CDD:275368	8/19 (42%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
		C2H2 Zn finger	578..598	CDD:275368	7/19 (37%)
		zf-H2C2_2	590..615	CDD:290200	11/24 (46%)
		C2H2 Zn finger	606..626	CDD:275368	5/19 (26%)
		C2H2 Zn finger	634..654	CDD:275368	6/19 (32%)
		zf-H2C2_2	646..671	CDD:290200	13/24 (54%)
		C2H2 Zn finger	662..682	CDD:275368	9/19 (47%)
		C2H2 Zn finger	690..710	CDD:275368	9/19 (47%)
		C2H2 Zn finger	718..738	CDD:275368	7/19 (37%)
		C2H2 Zn finger	746..766	CDD:275368	10/19 (53%)
		C2H2 Zn finger	774..794	CDD:275368	9/19 (47%)
		zf-H2C2_2	786..810	CDD:290200	12/23 (52%)
		C2H2 Zn finger	802..822	CDD:275368	8/19 (42%)
		zf-H2C2_2	814..838	CDD:290200	4/7 (57%)
		C2H2 Zn finger	830..850	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900