DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and BC024063

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001360962.1	Gene:	BC024063 / 666584	MGIID:	2670978	Length:	749	Species:	Mus musculus

Alignment Length:	464	Identity:	185/464 - (39%)
Similarity:	259/464 - (55%)	Gaps:	17/464 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NFC----SYGKDLEPVKGV-----PSKLKTCKSKIAKKRPLRKQ------TDTFKCTQCQKTFTR 93
            |.|    :|.:.||..:..     |.:...|....|....||..      ...|.||||.|.||.
Mouse   249 NECGRAFAYSRALEAHEKTHTGEKPYECNQCSKAFASHASLRNHLKHHTGEKFFVCTQCGKAFTS 313

  Fly    94 KENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLH 157
            :..|..|.|.|..|:|:|||.|.|:|..:::.:.|...|. ::|::|:||.|.||.:::|:.|..
Mouse   314 QSILHRHERTHTGEKPYECSQCGKAFALQSYLQIHKRTHTGEKPYECNHCGKAFTSHANLQNHEK 378

  Fly   158 EHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFK 222
            .||||:|:.|.||..:|...|.||:|.|:|:..:|:||..|.|||.:.|::|.|.|.|...:|:.
Mouse   379 HHTGEKPYGCNQCGKAFVCSSSLQIHERSHTGNKPYECNQCGKAFTSRSYIQIHERIHTGEKPYG 443

  Fly   223 CSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFA 286
            |..|.|:|...|.||.|..:| .|:.|:||.|.|.|.....|:||.|||.||.|::|.||.|.||
Mouse   444 CKQCGKAFAYSSSLQIHERSHTGEKLFECTHCSKAFASRSYLRIHKRVHTGEKPYECNHCGEAFA 508

  Fly   287 RNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQ 351
            ....||.|...|.|::|..|:||...||.||..::|.|:||.|:.|.|.:|.|:|..|..|..|:
Mouse   509 SRGSLQNHEKHHTGEKPYGCNQCGKVFARRSNLQIHERIHTGEKPYGCKQCGKAFVLKRDLQIHE 573

  Fly   352 QVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQF 416
            ::||||:|:.|..|.|.|.|.:.|::|...|.|||..:|:.|.|.|...|.|.:|.:.|||:..:
Mouse   574 RIHTGEKPYGCKQCGKAFVCSSSLKIHERSHTGEKPCECNQCGKAFASRSYLQIHKRVHTGEKPY 638

  Fly   417 ECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRY 481
            ||..|.|::.:.|.|.:|.|||||:.|.:|:.|.|.|...:..|.|.|.|||||||.|:.|...:
Mouse   639 ECNLCGKAFVSHSYLQVHKRTHTGQKPNECNQCGKAFVSHSYLQIHKRLHTGEKPYGCNQCGKAF 703

  Fly   482 TQKSSLGRH 490
            |....|.||
Mouse   704 TYNRDLHRH 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	172/411 (42%)
		C2H2 Zn finger	84..104	CDD:275368	10/19 (53%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	12/24 (50%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..326	CDD:275368	9/19 (47%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
BC024063	NP_001360962.1	KRAB	4..44	CDD:366587
		C2H2 Zn finger	109..128	CDD:275368
		COG5048	132..489	CDD:227381	87/239 (36%)
		C2H2 Zn finger	136..156	CDD:275368
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	192..212	CDD:275368
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368	5/18 (28%)
		C2H2 Zn finger	276..296	CDD:275368	4/19 (21%)
		C2H2 Zn finger	304..324	CDD:275368	10/19 (53%)
		COG5048	312..736	CDD:227381	168/401 (42%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		C2H2 Zn finger	528..548	CDD:275368	9/19 (47%)
		C2H2 Zn finger	556..576	CDD:275368	7/19 (37%)
		C2H2 Zn finger	584..604	CDD:275368	7/19 (37%)
		C2H2 Zn finger	612..632	CDD:275368	7/19 (37%)
		C2H2 Zn finger	640..660	CDD:275368	7/19 (37%)
		C2H2 Zn finger	668..688	CDD:275368	7/19 (37%)
		C2H2 Zn finger	696..716	CDD:275368	6/17 (35%)
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900