Protein Alignment CG5245 and ZNF732

DIOPT Version :10

• Sequence 1: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001131080.1
• Gene: ZNF732 / 654254
• HGNCID: 37138
• Length: 585
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 170/562 - (30%)
• Similarity: 260/562 - (46%)
• Gaps: 92/562 - (16%)

  Fly    14 EPPQEDTFEEEL-----------IFISNSD----FEELESEIKIE---------NFCS-YGKDLE 53
            :|.|::.:.:.:           :.|||.|    .|:.:...|::         ..|| :.:|..
Human    22 DPAQQNLYRDVMLENYRNLISLGVAISNPDLVIYLEQRKEPYKVKIHETVAKHPAVCSHFTQDFL 86

  Fly    54 PVKGVPSKL-------------------KTCKSKIAK------KRPLRK-QTDTFKCT------- 85
            ||:|:....                   |:||.|:.|      .:.|.. |:..|:|.
Human    87 PVQGIEDSFHKLILRRYEKCGHENLELRKSCKRKVQKGGYNEFNQCLSTIQSKIFQCNVHVKVFS 151

  Fly    86 -------------------QCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLK 131
                               :|.|:|.:..:|..|..:||.|:|:.|..|.|.|      |.:|:.
Human   152 TFSNSNQRRIRHTGEKHFKECGKSFQKFSDLTQHQGIHAGEKPYTCEECGKDF------KWYLIF 210

  Fly   132 HE-------KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSE 189
            :|       ::|..|..|...||.:|:..:| ..||||:.:|..:|..:|.|.|.|..|.|.|:|
Human   211 NEYEIIHTGEKPFTCEECGNIFTTSSNFAKH-KVHTGEKSYKYEECGKAFNRSSTLTKHKRIHAE 274

  Fly   190 ERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQC 253
            |:||.|..|.|...::|::.:|.:.|...:.:||..|.|.|...:.|.||...| .|:.:.|.:|
Human   275 EKPFTCEECGKIITSSSNVAKHKKIHTGEKLYKCQECGKVFNRSTTLTKHNRIHTGEKPYTCEEC 339

  Fly   254 PKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSL 318
            .|.|.::..|..|.|:|.||.|:||..|.:.|.:::.|..|...|.|::|..|.:|...|:..:.
Human   340 GKAFSRSSVLNEHKRIHTGEKPYKCEQCGKAFRQSATLNKHKSIHTGEKPYTCEECGKAFSRFTT 404

  Fly   319 YRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHI 383
            ...|.|:||.||.:||.||.|:|...:.|.:|:.:||||:|:||..|.|.|....:|..|...|.
Human   405 LNEHKRIHTGERPHKCEECGKAFGWSTDLNKHKIIHTGEKPYKCEECGKAFGWSAYLSKHKKIHT 469

  Fly   384 GEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSH 448
            |||..:|..|.|.|..|..|..|...|||:..:||..|.|::..|:.|..|.:.||||.|::|..
Human   470 GEKPYRCEECGKAFLCSRALNKHKTIHTGEKPYECEECGKAFGWSTYLSKHKKIHTGEKPYRCEE 534

  Fly   449 CSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |.|.|.||....::...|||:|..||..|...:...|.|.:|
Human   535 CGKAFRRSRVLNKYKTIHTGDKTPKCKGCGKAFKWSSYLNQH 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	147/438 (34%)
		C2H2 Zn finger	84..104	CDD:275368	6/45 (13%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	5/19 (26%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
ZNF732	NP_001131080.1	KRAB	4..62	CDD:214630	7/39 (18%)
		COG5048	130..542	CDD:227381	139/418 (33%)
		C2H2 Zn finger	143..163	CDD:275368	1/19 (5%)
		C2H2 Zn finger	170..189	CDD:275368	5/18 (28%)
		C2H2 Zn finger	225..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	253..272	CDD:275368	7/18 (39%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275368	6/19 (32%)
		C2H2 Zn finger	560..579	CDD:275368	5/17 (29%)