DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and ZNF667

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001308285.1	Gene:	ZNF667 / 63934	HGNCID:	28854	Length:	610	Species:	Homo sapiens

Alignment Length:	587	Identity:	170/587 - (28%)
Similarity:	272/587 - (46%)	Gaps:	116/587 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TFEEELIFISNSDFE-------ELESEIKIENF------------------CSYGKD---LEPV- 55
            ||.:..|:.|..::|       :|..::.:||:                  ...||.   :|||
Human    15 TFGDLAIYFSQEEWEWLSPIQKDLYEDVMLENYRNLVSLGLSFRRPNVITLLEKGKAPWMVEPVR 79

  Fly    56 -KGVPSKLKTCKSK--------------------IAKKRPLRKQ-----------------TDTF 82
             :..|.....|::|                    ..:|.|.||.                 ....
Human    80 RRRAPDSGSKCETKKLPPNQCNKSGQSICQKLVSAQQKAPTRKSGCNKNSVLVKPKKGHSGKKPL 144

  Fly    83 KCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKTF 146
            ||..|.|||:|..:|:.|..:|..|:|||||:|.|:|.:.:....|...|. |:.|:|:.|.::|
Human   145 KCNDCGKTFSRSFSLKLHQNIHTGEKPFECSNCRKAFRQISSILLHQRIHSGKKSHECNKCGESF 209

  Fly   147 TQNSSLKQHLHEHTGERPF-------------------------KCTQCSTSFARKSHLQVHLRT 186
            .|.::|..|:..|.|:...                         :|.:|..:|.:.|.|.:|.:.
Human   210 NQRTTLILHMRIHDGKEILDCGKALSQCQSFNIHQKIHVVGNVCQCRKCGKAFNQMSSLLLHKKI 274

  Fly   187 HSEERPFECTHCEKAFKNNS--------HLQEHL-------------RTHQEARPFKCSHCSKSF 230
            |:.::..:...|.:.||..|        |..|.:             |:|....||||..|.|.|
Human   275 HNGKKTHKYNKCGRGFKKKSVFVVHKRIHAGEKIPENAKALSQSLQQRSHHLENPFKCRKCGKLF 339

  Fly   231 KLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLH 294
            ...|.|..|...| :|:.:||.:|.|.|.:..:|.:|||:|.||..::|..|.:...|:|.|..|
Human   340 NRISPLMLHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCEKVCNRHSSLIQH 404

  Fly   295 LLEHAGKEPL-KCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGER 358
            ...|..|:.| :|.:|...|:..:..::|..:|:.|:.:||.:|||.|.::|.|:|||::||||:
Human   405 QKVHTKKKKLFECKECGKMFSGTANLKIHQNIHSEEKPFKCNKCSKVFGRQSFLIEHQRIHTGEK 469

  Fly   359 PFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSK 423
            |::|..|.|.|..|..|..|...|..::..:|..|.|.|..|:.|..|.:.|||:..:.|..|.|
Human   470 PYQCEECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAFSQSAHLAQHERIHTGEKPYTCKTCGK 534

  Fly   424 SYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLG 488
            :::..::|.:|.|:||||.|::|:.|.|.|:..::...|.|:|:.||||:||.|...|::.|||.
Human   535 AFSQRTSLILHERSHTGEKPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLI 599

  Fly   489 RH 490
            ||
Human   600 RH 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	146/469 (31%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	5/24 (21%)
		C2H2 Zn finger	195..215	CDD:275368	7/40 (18%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	4/19 (21%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	9/17 (53%)
ZNF667	NP_001308285.1	KRAB	15..74	CDD:214630	10/58 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..139		3/19 (16%)
		COG5048	141..601	CDD:227381	148/459 (32%)
		C2H2 Zn finger	146..166	CDD:275368	8/19 (42%)
		C2H2 Zn finger	174..194	CDD:275368	6/19 (32%)
		C2H2 Zn finger	202..222	CDD:275368	6/19 (32%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	284..303	CDD:275368	4/18 (22%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
		C2H2 Zn finger	445..465	CDD:275368	10/19 (53%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	501..521	CDD:275368	7/19 (37%)
		C2H2 Zn finger	529..549	CDD:275368	6/19 (32%)
		C2H2 Zn finger	557..577	CDD:275368	6/19 (32%)
		C2H2 Zn finger	585..605	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000