DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5245 and Gm6710

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001158161.1	Gene:	Gm6710 / 626832	MGIID:	3779623	Length:	554	Species:	Mus musculus

Alignment Length:	550	Identity:	193/550 - (35%)
Similarity:	288/550 - (52%)	Gaps:	52/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLANVDQRPV---KDE-----PPQEDTFEEELI---------------FISNSDFEELESEIKI 42
            |||...|...|   :||     |.|:..:::.::               ......|:...|..:.
Mouse     1 MDLVTYDDVQVNFTQDEWALLDPSQKSLYKDVMLETYRNLTAIGYIWEEHTIEDHFQTSRSHGRH 65

  Fly    43 ENFCS-----------------YGKDLEPVKGVPSKLKTCKS-----KIAKKRPLRKQTDT---- 81
            |..||                 .|:....:|....|...|..     :......:.|:|.|
Mouse    66 ERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKDFRTWNVLQIHKRTHTGEKP 130

  Fly    82 FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSKSFGRRTHYKRHLLKHE-KRPHKCSHCSKT 145
            :.|.||.|.|.|..:|:.|.|.||.|:.:||:.|.|:..||:..:.|...|. ::|::|:.|.|.
Mouse   131 YDCKQCGKVFARSCHLQIHNRTHAGEKQYECNQCGKALKRRSDLQIHKRTHTGEKPYECNQCGKA 195

  Fly   146 FTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQE 210
            |..:..|:||...||||:|::|.||..:|:..|||::|.|||:.|:|:||..|.|||.::|||.:
Mouse   196 FASSGDLQQHKRTHTGEKPYECKQCGKAFSECSHLRIHKRTHTGEKPYECKQCGKAFAHSSHLHK 260

  Fly   211 HLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGED 274
            |.|||...:|::|:.|.|:|.:...||.|..|| .::.::|.||.|.|....:||:|.|.|.|:.
Mouse   261 HERTHTGDKPYECNQCGKAFAVIYTLQMHKRTHTGDKPYECNQCGKAFAVIYTLQMHKRTHTGDK 325

  Fly   275 PFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSK 339
            |::|..|.:.||....||.|...|.|::|.||.||...|......|:|.|.||.|:.|:|.:|.|
Mouse   326 PYECNQCGKAFAVIYTLQRHKQTHTGEKPYKCKQCGKAFTRSCHLRIHKRTHTGEKPYECNQCGK 390

  Fly   340 SFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLL 404
            :|.:...|.:|::.||||:|::|..|.|.|...:||..|...|.|:|..:|:.|.|.|..||.|.
Mouse   391 AFARSGDLQKHKRTHTGEKPYECKQCGKAFAHSSHLHKHERTHTGDKPYECNQCGKAFAESSTLQ 455

  Fly   405 VHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGE 469
            :|.:.|||:..:||..|.|::.|...|.:|.||||||.|::|..|.|.||.|::.|:|.|||:|.
Mouse   456 IHNRTHTGEKPYECNQCGKAFITRRVLQIHKRTHTGEKPYECKQCGKAFASSSDLQKHKRTHSGA 520

  Fly   470 KPYKCSHCSTRYTQKSSLGRHLRRTLCGTK 499
            |||:|..|...:.|.|.|..| ::|..|.:
Mouse   521 KPYECKQCGKAFAQSSHLRIH-KQTHTGER 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	168/409 (41%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	9/19 (47%)
		zf-H2C2_2	179..204	CDD:290200	14/24 (58%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
Gm6710	NP_001158161.1	KRAB	3..44	CDD:366587	7/40 (18%)
		C2H2 Zn finger	79..97	CDD:275368	1/17 (6%)
		C2H2 Zn finger	105..125	CDD:275368	2/19 (11%)
		COG5048	129..515	CDD:227381	157/385 (41%)
		C2H2 Zn finger	133..153	CDD:275368	9/19 (47%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		C2H2 Zn finger	217..237	CDD:275368	9/19 (47%)
		C2H2 Zn finger	245..265	CDD:275368	10/19 (53%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	9/19 (47%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..517	CDD:275368	9/19 (47%)
		zf-H2C2_2	509..534	CDD:372612	11/24 (46%)
		C2H2 Zn finger	525..545	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810