DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5245 and Zfp872

DIOPT Version :9

Sequence 1:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001028985.1	Gene:	Zfp872 / 619310	MGIID:	3588272	Length:	465	Species:	Mus musculus

Alignment Length:	484	Identity:	162/484 - (33%)
Similarity:	247/484 - (51%)	Gaps:	51/484 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EELIFISNSDFEELESEI---KIENFCSYGKDLEPVKGVPSKLKTCKSKIAKKRPLRKQTDTFKC 84
            ||...:.:|. :||..::   .::|..|.|::.:                  .:.:|.|..|
Mouse    16 EEWALLDDSQ-KELYQDVMQETVDNLASIGENWQ------------------DQSIRDQCKT--- 58

  Fly    85 TQCQKTFTRKENLESHLRLHAEERPFEC-SHCSKSFGRRTHYK-RHLLKHEKRPHKCSHCSKTFT 147
                        ...::..|.|:||.|. |.|.:.|.:....| :|:|...| |.:|..|.|.::
Mouse    59 ------------QGKYISAHVEQRPREWKSACREVFTQLPALKQQHILPGVK-PCECGICGKVYS 110

  Fly   148 QNSSLKQHLH---EHT-----GERP--FKCTQCSTSFARKSHLQVHLRTHSEERPFECTHCEKAF 202
            ..||||:|:.   |||     |.|.  ::|..|..:|:.:|..::|.|||:.|:|:.|..|.|||
Mouse   111 CRSSLKRHMQCHSEHTQWESHGFRGKLYQCKDCGKAFSFQSSFRIHERTHTGEKPYMCKECGKAF 175

  Fly   203 KNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTHA-ERSFKCTQCPKTFLQNDSLQIH 266
            ..::..|.|:|.|...:|:||..|.|:|...|:.:.|...|: |:.::|.||.|||....:.|:|
Mouse   176 IYHTTYQGHMRMHTGEKPYKCKECGKAFSHPSLFRNHERAHSGEKPYECKQCGKTFRYYQTFQLH 240

  Fly   267 LRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQ 331
            .|.|.||.|::|..|.:..:|::..:.|...|.|::|.||.:|...|...|.:|.|.|:||.||.
Mouse   241 ERTHTGEKPYQCKQCGKALSRSTSFRSHERIHTGEKPYKCRKCGKAFRFPSSFRKHERIHTDERP 305

  Fly   332 YKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKE 396
            |.|.||.|:|........|..:|||..|:||..|.|.|.|.:...:|...|.|||..:|..|.|.
Mouse   306 YDCKECGKAFISLPSFRRHVILHTGNGPYKCKECGKAFDCPSSFHIHERTHTGEKPHECQRCGKA 370

  Fly   397 FKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQE 461
            |..:|.:.:|.:.|||:..:||..|.|::::||:..||.|.||||.|::|..|.|.|:.|:..:.
Mouse   371 FSCASSVRIHERTHTGEKPYECKQCGKAFSSSSSFRMHERIHTGEKPYECRQCGKAFSFSSSFRM 435

  Fly   462 HLRTHTGEKPYKCSHCSTRYTQKSSLGRH 490
            |.|||.|||||:|..|...::..||...|
Mouse   436 HERTHKGEKPYECKQCGKAFSSSSSFHMH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/416 (36%)
		C2H2 Zn finger	84..104	CDD:275368	0/19 (0%)
		C2H2 Zn finger	112..132	CDD:275368	6/21 (29%)
		C2H2 Zn finger	139..159	CDD:275368	8/22 (36%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		zf-H2C2_2	179..204	CDD:290200	11/24 (46%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	4/19 (21%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Zfp872	NP_001028985.1	KRAB	4..>44	CDD:214630	7/28 (25%)
		KRAB	4..43	CDD:279668	6/27 (22%)
		C2H2 Zn finger	78..94	CDD:275368	4/15 (27%)
		C2H2 Zn finger	102..122	CDD:275368	8/19 (42%)
		C2H2 Zn finger	140..160	CDD:275368	6/19 (32%)
		zf-H2C2_2	152..177	CDD:290200	11/24 (46%)
		COG5048	164..>449	CDD:227381	111/284 (39%)
		C2H2 Zn finger	168..188	CDD:275368	8/19 (42%)
		zf-H2C2_2	184..205	CDD:290200	9/20 (45%)
		C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		C2H2 Zn finger	224..244	CDD:275368	9/19 (47%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..287	CDD:290200	7/22 (32%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		zf-H2C2_2	376..401	CDD:290200	8/24 (33%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		zf-H2C2_2	404..428	CDD:290200	11/23 (48%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900